ABC | Volume 112, Nº5, May 2019

Original Article Andrade et al Stent versus CABG: a meta-analysis Arq Bras Cardiol. 2019; 112(5):511-523 Table 1 – Overview of clinical trials Study Origin Period of recruitment Number of Patients Disease extension Characteristics Unstable angina (%) Average ejection fraction (%) Off pump surgery (%) Diabetics (%) AWESOME North America (USA) 1995-2000 454 Two and three vessel disease BMS. Previous CABG included 36 45 0 32 ARTS International 1997-2000 1205 Two and three vessel disease BMS. Majority two vessel disease 30 61 0 21 ERACI II South America (Argentina) 1996-1998 450 Two and three vessel disease BMS. Majority unstable angina 92 ND 0 17 SOS Europe and Canada 1995-1999 988 Two and three vessel disease BMS. Majority two vessel disease 33 ND 3 15 MASS II South America (Brazil) 1995-2000 408 Two and three vessel disease BMS. Clinical arm 36 65 0 30 LEMANS Europe (Poland) 2001-2004 105 Left main coronary disease BMS and DES DES if LM < 3.8 32 53 0 25 SYNTAX Europe and USA 2005-2007 1800 Left main and three vessel disease DES (Taxus) 28 ND 15 35 CARDia Europe (United Kingdom) 2002-2007 510 Two and three vessel disease BMS and DES. Only diabetics. 22 59 31 100 Boudriot et al Europe (Germany) 2003-2009 201 Left main coronary disease DES (Sirolimus) ND ND 46 30 PRECOMBAT Asia (Korea) 2003-2009 600 Left main coronary disease DES (Everolimus) 45 60 64 42 FREEDOM International 2005-2010 1900 Two and three vessel disease DES. Only diabetes 30 65 19 100 Va-Cards North America (USA) 2006-2010 198 Two and three vessel disease DES. Only diabetics ND ND ND 100 BEST Asia (Korea) 2008-2013 880 Two and three vessel disease DES. (Everolimus) 42 59 64 45 EXCEL International 2010-2014 1905 Left main coronary disease DES. (Everolimus) 37 57 29 25 NOBLE Europe 2008-2015 982 Left main coronary disease DES (Biolimus) 18 60 16 18 AWESOME: Angina with extremely severe outcomes; ERACI II: Argentine randomized study: coronary angioplasty with stenting versus coronary bypass surgery in patients with multivessel disease; MASS II: Medicine, Angioplasty, or Surgery Study; ARTS: Arterial Revascularization Therapies Study; SOS: Stent or Surgery trial. SYNTAX: Synergy between PCI with Taxus and Cardiac Surgery; CARDia: Coronary artery revascularization in diabetic; Le Mans: Left main stenting; FREEDOM: Future Revascularization Evaluation in Patients with Diabetes Mellitus; Va-Cards: Coronary Artery Revascularization in Diabetes in VA Hospitals; BEST: Bypass Surgery and Everolimus-Eluting Stent Implantation in the Treatment of Patients with Multivessel Coronary Artery Disease; PRECOMBAT: Premier of Randomized Comparison of Bypass Surgery versus Angioplasty Using Sirolimus-Eluting Stent in Patients with Left Main Coronary Artery Disease; EXCEL: Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization; NOBLE: Nordic-Baltic-British Left Main Revascularization Study. Boldriot et al: J Am Coll Cardiol. 2011; 57: 538-545. DES: drug-eluting stent; BMS: bare-metal stent. 514