ABC | Volume 112, Nº4, April 2019

Original Article Philbois et al Obesity and barorreflex sensitivity Arq Bras Cardiol. 2019; 112(4):424-429 1. Yildirir A, Aybar F, Kabakci G, Yarali H, Oto A. Heart rate variability in young women with polycystic ovary syndrome. Ann Noninvasive Electrocardiol. 2006;11(4):306-12. 2. TekinG, Tekin A, Kiliçarslan EB, Haydardedeoğlu B, Katircibaşi T, KoçumT, et al. Altered autonomic neural control of the cardiovascular system in patients with polycystic ovary syndrome. Int J Cardiol. 2008;130(1):49-55. 3. de Sá JC, Costa EC, da Silva E, Zuttin RS, da Silva EP, Lemos TM, et al. Analysis of heart rate variability in polycystic ovary syndrome. Gynecol Endocrinol. 2011;27(6):443-7. 4. Saranya K, Pal GK, Habeebullah S, Pal P. Assessment of cardiovascular autonomic function in patients with polycystic ovary syndrome. J Obstet Gynaecol Res. 2014;40(1):192-9. 5. La Rovere MT, Bigger JT, Marcus FI, Mortara A, Schwartz PJ. Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators. Lancet. 1998;351(9101):478-84. 6. Tank J, Jordan J, Diedrich A, Obst M, Plehm R, Luft FC, et al. Clonidine improves spontaneous baroreflex sensitivity in conscious mice through parasympathetic activation. Hypertension. 2004;43(5):1042-7. 7. Kouchaki Z, Butlin M, Qasem A, Avolio AP. Assessment of baroreflex sensitivity by continuous noninvasive monitoring of peripheral and central aortic pressure. Conf Proc IEEE Eng Med Biol Soc. 2014;2014:2940-3. 8. Kuppusamy S, Pal GK, Habeebullah S, Ananthanarayanan PH, Pal P. Association of sympathovagal imbalancewith cardiovascular risks in patients with polycystic ovary syndrome. Endocr Res. 2015;40(1):37-43. 9. Sztajzel J, Golay A, Makoundou V, Lehmann TN, Barthassat V, Sievert K, et al. Impact of body fat mass extent on cardiac autonomic alterations in women. Eur J Clin Invest. 2009;39(8):649-56. 10. ThaisaHRDS,GastaldiAC,IzabelaCC,JoãoEA,SuenimeireV,HugoCDS.Effects ofPhysicalTrainingonCardiacModulation inNormalWeight,Overweight,and ObeseI ndividuals:AComparativeStudy.JNutrFoodSci. 2015:5(6):1-7. 11. Lambert EA, Teede H, Sari CI, Jona E, Shorakae S, Woodington K, et al. Sympathetic activation and endothelial dysfunction in polycystic ovary syndrome are not explained by either obesity or insulin resistance. Clin Endocrinol (Oxf). 2015;83(6):812-9. 12. Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41-7. 13. Griffin IJ,ColeTJ,DuncanKA,HollmanAS,DonaldsonMD.Pelvicultrasound measurements in normal girls. Acta Paediatr. 1995;84(5):536-43. 14. World Health Organization (WHO). Global status report on noncommunicable diseases 2010: Description of the global burden of NCDs, their risk factors and determinants. Geneva: World Health Organization; 2011. 15. Welch Be, Riendeau Rp, Crisp Ce, Isenstein Rs. Relationship of maximal oxygen consumption to various components of body composition. J Appl Physiol. 1958;12(3):395-8. 16. van de Borne P, Montano N, Zimmerman B, Pagani M, Somers VK. Relationship between repeated measures of hemodynamics, muscle sympathetic nerve activity, and their spectral oscillations. Circulation. 1997;96(12):4326-32. 17. Billman GE. Heart rate variability - a historical perspective. Front Physiol. 2011 Nov 29;2:86. 18. Heartratevariability:standardsofmeasurement,physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation. 1996;93(5):1043-65. 19. Montano N, Ruscone TG, Porta A, Lombardi F, Pagani M, Malliani A. Power spectrum analysis of heart rate variability to assess the changes in sympathovagal balance during graded orthostatic tilt. Circulation. 1994;90(4):1826-31. References Conclusion Although PCOS is an endocrine-metabolic disease that causes several body changes, it does not alter the autonomic cardiovascular control. However, the association with obesity resulted in a decrease in BRS values, and attenuated the HRV values. Suggesting that obesity may play a role in change hemodynamics parameters and cardiovascular autonomic control. However, further studies should be conducted to investigate the effects of metabolic and hormonal changes in these women and the association of these changes with cardiovascular autonomic control. Author contributions Conception and design of the research: Philbois SV, Souza HCD; acquisition of data: Philbois SV, Facioli TP, Felix ACS; analysis and interpretation of the data and critical revision of the manuscript for intellectual content: Philbois SV, Gastaldi AC, Souza HCD; statistical analysis: Philbois SV, Facioli TP; obtaining funding: Souza HCD; writing of the manuscript: Gastaldi AC, Souza HCD. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding This study was funded by CNPQ 457216/2014-0. Study Association This article is part of the thesis of master submitted by Stella Vieira Philbois, from Faculdade de Medicina de Ribeirão Preto. Ethics approval and consent to participate This study was approved by the Ethics Committee of the Hospital das Clínicas de Ribeirão Preto e da Faculdade de Medicina de Ribeirão Preto under the protocol number 11487/2014. All the procedures in this study were in accordance with the 1975 Helsinki Declaration, updated in 2013. Informed consent was obtained from all participants included in the study. 428