ABC | Volume 112, Nº3, March 2019

Original Article Bittencourt et al Myocardial fibrosis in hypertrophic cardiomyopathy Arq Bras Cardiol. 2019; 112(3):281-289 Figure 3 – Forest plot of the risk markers and the relative risk of severe arrhythmic outcomes:A: unexplained syncope; B: severe ventricular hypertrophy; C: family history of sudden death; D: non-sustained ventricular tachycardia; E: abnormal blood pressure response to exercise; F: left ventricular outflow tract obstruction. TE: estimated treatment effect; seTE: standard error of treatment estimate; RR: relative risk; 95%CI: 95% confidence interval. 0.2 0.5 2 1 5 0.2 0.5 2 1 5 0.2 0.5 21 5 1.35 0.3071 0.64 0.5016 0.94 0.2579 –0.60 0.7827 1.43 0.2099 0.87 0.7705 1.03 0.3536 1.93 0.9765 2.33 1.1253 0.59 0.3650 1.19 0.6019 0.93 0.1605 0.92 0.3947 0.54 0.7436 0.35 0.3536 0.59 0.4689 0.36 0.2575 0.85 0.3940 –0.23 0.6250 0.34 0.5253 1.34 0.4462 0.88 0.4166 0.64 0.2953 0.23 0.4505 –0.69 0.5503 3.84 8.6% 9.5% [2.10; 7.01] 1.90 3.2% 3.9% [0.71; 5.08] 2.57 12.2% 12.8% [1.55; 4.26] 0.55 1.3% 1.6% [0.12; 2.55] 4.18 18.5% 17.7% [2.77; 6.31] 2.38 1.4% 1.7% [0.53; 10.78] 2.80 6.5% 7.4% [1.40; 5.60] 6.90 0.9% 1.1% [1.02; 46.78] 10.25 0.6% 0.8% [1.13; 92.98] 1.80 6.1% 7.0% [0.88; 3.68] 1.80 6.1% 7.0% [0.88; 3.68] 2.53 31.6% 25.9% [1.85; 3.47] 2.50 5.2% 6.1% [1.15; 5.42] 1.71 1.5% 1.8% [0.40; 7.34] 1.42 19.9% 19.9% [0.71; 2.84] 1.80 11.3% 11.3% [0.72; 4.51] 1.43 37.5% 37.5% [0.86; 2.37] 2.35 16.0% 16.0% [1.08; 5.08] 0.79 6.4% 6.4% [0.23; 2.70] 1.40 9.0% 9.0% [0.50; 3.92] 3.82 16.5% 19.2% [1.59; 9.16] 2.41 18.9% 20.4% [1.07; 5.45] 1.90 37.6% 25.9% [1.07; 3.39] 1.26 16.2% 19.0% [0.52; 3.05] 0.50 10.8% 15.5% [0.17; 1.47] 100.0% 100.0% 2.81 2.79 [2.35; 3.35] [2.29; 3.41] -- -- 100.0% 100.0% 1.53 1.53 [1.12; 2.08] [1.12; 2.08] -- -- 100.0% 100.0% 1.81 1.72 [1.27; 2.57] [0.97; 3.02] -- -- Elliott PM et al., 2006 Elliott PM et al., 2000 Gimeno JR et al., 2009 Kofflard MJ et al., 1993 Maron BJ et al., 2007 Rubinshtein R et al., 2010 Michaelides AP et al., 2009 Monserrat L et al., 2003 Syska P et al., 2010 Magnusson et al., 2016 Klopotoeski et al., 2015 Mahony et al., 2014 Debonmaire et al., 2015 Ismail et al., 2014 Fixed effect model Random effects model Heterogeneity: I 2 = 10%, τ 2 = 0.0138, p = 0.35 Elliott PM et al., 2006 Spirito P et al., 2014 Gimeno JR et al., 2009 Maron MS et al., 2003 Ismail et al., 2014 Fixed effect model Random effects model Heterogeneity: I 2 = 58%, τ 2 = 0.2343, p = 0.05 Elliott PM et al., 2006 Elliott PM et al., 2000 Gimeno JR et al., 2009 Michaelides AP et al., 2009 Syska P et al., 2010 Magnusson et al., 2016 Fixed effect model Random effects model Heterogeneity: I 2 = 0%, τ 2 = 0, p = 0.77 Study TE seTE Risk Ratio RR 95%-Cl Weight (fixed) Weight (random) Study TE seTE Risk Ratio RR 95%-Cl Weight (fixed) Weight (random) Study TE seTE Risk Ratio RR 95%-Cl Weight (fixed) Weight (random) D E F 287