ABC | Volume 112, Nº2, February 2019

Original Article Maifrino et al Exercise effects on ovariectomized mice Arq Bras Cardiol. 2019; 112(2):180-188 1. Raskin P, Bode BW, Marks JB, Hirsch IB, Weinstein RL, McGill JB, et al. Continuous subcutaneous insulin infusion and multiple daily injection therapy are equally effective in type 2 diabetes: a randomized, parallel- group, 24-week study. Diabetes Care. 2003;26(9):2598-603. 2. De Lorenzi DRS, Basso E, Fagundes PO, Saciloto B. Prevalence of overweight and obesity among climacteric women. Rev Bras Ginecol Obstet. 2005;27(8):479-84. 3. OliveiraF,MaifrinoLB,JesusGP,CarvalhoJG,MarchonC,RibeiroDA.Therole of cyclooxygenase-2 on endurance exercise training in female LDL-receptor knockoutovariectomizedmice.AnAcadBrasdeCienc.2013;85(3):1157-64. 4. Doshi SB, Agarwal A. The role of oxidative stress in menopause. J Midlife Health. 2013;4(3):140-6. 5. Berillis P. The role of collagen in the aorta’s structure. Open Circ Vasc J. 2013;6(1):1-8. 6. Saltiki K, Doukas C, Kanakakis J, Anastasiou E, Mantzou E, Alevizaki M. Severity of cardiovascular disease in women: relation with exposure to endogenous estrogen. Maturitas. 2006;55(1):51-7. 7. Marchon C, de Marco OE, Silva VKA, Lacchini S, de Souza RR, Fonseca FL, et al. Effects of moderate exercise on the biochemical, physiological, morphological and functional parameters of the aorta in the presence of estrogen deprivation and dyslipidemia: an experimental model. Cell Physiol Biochem. 2015;35(1):397-405. 8. Thompson P, Buchner D, Piña IL, Balady GJ, Williams MA, Marcus BH, et al. Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council onNutrition, Physical Activity, andMetabolism (Subcommittee on Physical Activity). Councilon Clinical Cardiology Circulation. 2003;107(24):3109-16. 9. Goto C, Higashi Y, Kimura M, Noma K, Hara K, Nakagawa K, et al. Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress. Circulation. 2003;108(5):530-5. 10. Silva JL, Maranhão RC, Vinagre M, Guilherme CG. Effects of resistance training on low density lipoprotein. Rev Bras de Med Esporte. 2010;16(1):71-6. 11. Nishida N, Arizumi T, Takita M, Kitai S, Yada N, Hagiwara S, et al. Reactive oxygen species induce epigenetic instability though the formation of 8-Hydroxyguanosine in human hepatocarcinogenesis. Digestive Diseases 2013;31(5-6):459-66. 12. Plachetka A, Adamek B, Strzelczyk JK, Krakowczyk Ł, Migula P, Nowak P, et al. 8-hidroxy-2’-deoxyguanosine in colorectal adenocarcinoma--is it a result of oxidative stress? Med Sci Monit. 2013 Aug 21;19:690-5. 13. Carmeli E, Moas M, Reznick AZ, Coleman R. Matrixmetalloproteinases and skeletal muscle: a brief review. Muscle Nerve. 2004;29(2):191-7. 14. Pasterkamp G, Schoneveld AH, Hijnen DJ, de Kleijn DP, Teepen H, van der Wal AC, et al. Atherosclerotic arterial remodeling and the localization of macrophages andmatrixmetalloproteases 1, 2 and 9 in the human coronary artery. Atherosclerosis. 2000;150(2):245-53. 15. ValentinF,Bueb JL,KiefferP,TschirhartE,Atkinson J.Oxidativestressactivates MMP-2 in cultured human coronary smooth muscle cells. Fundam Clin Pharmacol. 2005;19(6):661-7. 16. Chow AK, Cena J, Schulz R. Acute actions and novel targets of matrix metalloproteinases in the heart and vasculature. Br J Pharmacol. 2007;152(2):189-205. 17. Fanjul-Fernández M, Folgueras AR, Cabrera S, Lopez-Otin C. Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models. Biochim Biophys Acta. 2010;1803(1):3-19. 18. Galis ZS, Khatri JJ. Matrix metalloproteinases in vascular remodeling and atherogenesis:thegood,thebad,andtheugly.CircRes.2002;90(3):251-62. 19. Nagase H, Woessner JF. Matrix metalloproteinases. J Biol Chem. 1999;274:21491-4. 20. Tayebjee MH, Nadar S, Blann AD, Gareth BD, MacFadyen RJ, Lip GY. Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in hypertension and their relationship to cardiovascular risk and treatment: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). Am J Hypertens. 2004;17(9):764-9. 21. Rodrigues FM, Adélio JI, Santana VO, DeMarcoOE, Souza RR, CardosoCG, et al. Physical exercise alters hepaticmorphology of low-density lipoprotein receptor knockout ovariectomized mice. Med Mol Morphol. 2018 Jun 22; [Epub ahead of print]. 22. Veloso AGB, Lima NEA, De Marco OE, Cardoso CG, Marques MR, Reis BCAA, et al. Effects of moderate exercise on biochemical, morphological, and physiological parameters of the pancreas of female mice with estrogen deprivation and dyslipidemia. Med Mol Morphol. 2018;51(2):118-27. 23. Maifrino LBM, AraújoRC, Faccini CC, Liberti EA, Gama EF, Ribeiro AACM, et al. Effect of exercise training on aging-induced changes in rat papillary muscle. Arq Bras Cardiol. 2009;92(5):387-92. 24. Triola MF. Introdução à estatística. 7. ed. Rio de Janeiro: LTC; 1999. 25. Marsh MM, Walker VR, Curtiss LK, Banka CL. Protection against atherosclerosis by estrogen is independent of plasma cholesterol levels in LDL receptor-deficient mice. J Lipid Res. 1999;40(5):893-900. 26. Irigoyen MC, Paulini J, Flores LJ, Flues K, Bertagnolli M, Moreira ED, et al. Exercisetrainingimprovesbaroreflexsensitivityassociatedwithoxidativestress reduction in ovariectomized rats. Hypertension. 2005;46(4):998-1003. 27. Desai KH, Sato R, Schauble E, Barsh GS, Kobilka BK, Bernstein D. Cardiovascular indexes in the mouse at rest and with exercise: new tools to studymodels of cardiac disease. Am J Physiol Heart Circ Physiol. 1997;272(2 Pt 2):H1053-61. 28. Corrado E, Rizzo M, Tantillo R, Muratori I, Bonura F, Vitale G, et al. Markers of inflammation and infection influence the outcome of patients with baseline symptomatic carotid lesions: a 5-year follow-up study. Stroke. 2006;37(2):482-6. 29. Qin B, Cao Y, Yang H, Xiao B, Lu Z. MicroRNA-221/222 regulate ox-LDL- induced endothelial apoptosis via Ets-1/p21 inhibition. Mol Cell Biochem. 2015;405(1-2):115-24. 30. Littlewood TD, Bennett MR. Apoptotic cell death in atherosclerosis. Curr Opin Lipidol. 2003;14(5):469-75. 31.Clarke MC, Littlewood TD, Figg N, Maguire JJ, Davenport AP, Goddard MR, et al. Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration. Circ Res. 2008;102(12):1529-38. 32. Schaub FJ,HanDK, LilesWC, Adams LD, Coats SA, Ramachandran RK, et al. Fas/FADD-mediated activation of a specific program of inflammatory gene expression in vascular smooth muscle cells. Nat Med. 2000;6(7):790-6. 33. Sandri M, Carraro U, Podhorska-Okolov M, Rizzi C, Arslan P, Monti D, et al. Apoptosis, DNA damage and ubiquitin expression in normal and mdx muscle fibers after exercise. FEBS Lett. 1995;373(3):291-5. 34. Goon JA, Noor Aini AH, Musalmah M, Yasmin Anum MY, Wan Ngah WZ. Long term Tai Chi exercise reduced DNA damage and increased lymphocyte apoptosisandproliferationinolderadults.MedJMalaysia.2008;63(4):319-24. 35. Mangge H, Becker K, Fuchs D, Gostner JM. Antioxidants, inflammation and cardiovascular disease. World J Cardiol. 2 014;6(6):462-77. 36. Xiang F, Shuanglun X, Jingfeng W, Ruqiong N, Yuan Z, Yongqing L, et al. Association of serum8-hydroxy-2’-deoxyguanosine levels with the presence and severity of coronary artery disease. Coron ArteryDis. 2011;22(4):223-7. 37. Sakalihasan N, Delvenne P, Nusgens BV, Limet R, Lapière CM. Activated forms of MMP2 and MMP9 in abdominal aortic aneurysms. J Vasc Surg. 1996;24(1):127-33. References 187