ABC | Volume 112, Nº2, February 2019

Original Article Badavi et al Trimetazidine effects on diabetic hearts Arq Bras Cardiol. 2019; 112(2):173-178 27. Badavi M, Abedi HA, Dianat M, Sarkaki AR. Exercise Training and Grape Seed ExtractCo-AdministrationImprovesLipidProfile,WeightLoss,Bradycardia,and HypotensionofSTZ-InducedDiabeticRats.IntCardiovascResJ.2013;7(4):111-7. 28. Vinik AI, Erbas T. Diabetic autonomic neuropathy. Handb Clin Neurol. 2013;117:279-94. 29. Zhang J, He S, Wang X, Wang D. Effect of trimetazidine on heart rate variability in elderly patients with acute coronary syndrome. Pak J Med Sci. 2016;32(1):75-8. 30. AdebiyiAO,AdebiyiOO,OwiraPM.NaringinMitigatesCardiacHypertrophy byReducingOxidativeStressand Inactivatingc-JunNuclearKinase-1Protein in Type I Diabetes. J Cardiovasc Pharmacol. 2016;67(2):136-44. 31. Al-Rasheed NM, Al-Rasheed NM, Hasan IH, Al-Amin MA, Al-Ajmi HN, Mahmoud AM. Sitagliptin attenuates cardiomyopathy by modulating the JAK/STAT signaling pathway in experimental diabetic rats. Drug Des Devel Ther. 2016 Jun 28;10:2095-107. 32. Prisacaru AE. Effect of antioxidants on polyunsaturated fatty acids - review. Acta Sci Pol Technol Aliment. 2016;15(2):121-9. 33. Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, Kaneda Y, et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature. 2000;404(6779):787-90. 34. Carillon J, Rugale C, Rouanet JM, Cristol JP, Lacan D, Jover B. Endogenous antioxidant defense induction by melon superoxide dismutase reduces cardiac hypertrophy in spontaneously hypertensive rats. Int J Food Sci Nutr. 2014;65(5):602-9. 35. Navarro-Arevalo A, Canavate C, Sanchez-del-Pino MJ. Myocardial and skeletal muscle aging and changes in oxidative stress in relationship to rigorous exercise training. Mech Ageing Dev. 1999;108(3):207-17. 36. Ulker S, McMaster D, McKeown PP, Bayraktutan U. Impaired activities of antioxidant enzymes elicit endothelial dysfunction in spontaneous hypertensive rats despite enhanced vascular nitric oxide generation. Cardiovasc Res. 2003;59(2):488-500. 37. Peixoto EB, Pessoa BS, Biswas SK, Lopes de Faria JB. Antioxidant SOD mimetic prevents NADPH oxidase-induced oxidative stress and renal damage in the early stage of experimental diabetes and hypertension. Am J Nephrol. 2009;29(4):309-18. This is an open-access article distributed under the terms of the Creative Commons Attribution License 178