ABC | Volume 112, Nº2, February 2019

Original Article Arq Bras Cardiol. 2019; 112(2):154-162 Naderi et al Garlic and exercise increase cardiac angiogenesis 26. Ueki K, Fruman DA, Yballe CM, Fasshauer M, Klein J, Asano T, et al. Positive andnegativerolesofp85 α andp85 β regulatorysubunitsofphosphoinositide 3-kinase in insulin signaling. J Biol Chem. 2003;278(48):48453-66. 27. Yu L, Di W, Dong X, Li Z, Xue X, Zhang J, et al. Diallyl trisulfide exerts cardioprotection against myocardial ischemia-reperfusion injury in diabetic state, role of AMPK-mediated AKT/GSK-3 β /HIF-1 α activation. Oncotarget. 2017;8(43):74791-74805. 28. Hayashida R, Kondo K, Morita S, Unno K, Shintani S, Shimizu Y, et al. Diallyl trisulfide augments ischemia-Induced angiogenesis via an endothelial nitric oxide synthase-dependent mechanism. Circ J. 2017;81(6):870-8. 29. Hakkila J. Studies on the myocardial capillary concentration in cardiac hypertrophy due to training; an experimental study with guinea pigs. Ann Med Exp Biol Fenn. 1955;33(Suppl 10):1-82. 30. Chan YC, Banerjee J, Choi SY, Sen CK. miR 210: The master hypoxamir. Microcirculation. 2012;19(3):215-23. 31. XUL,WANGF,WeiW, DAIW-q, HE S-s,WANGX-p, et al. Effects of hypoxia on the expressions of hypoxia-inducible factor-1 alpha and miR-210 in hepatocellular carcinoma HepG2 cells. Tumor. 2011;31(6):502-7. 32. Wang J, Zhang Y, Liu YM, Guo LL, Wu P, Dong Y, et al. Huoxue Anxin Recipe () promotes myocardiumangiogenesis of acutemyocardial infarction rats by up-regulating miR-210 and vascular endothelial growth factor. Chin J Integr Med. 2016;22(9):685-90. 33. Greco S, Fasanaro P, Castelvecchio S, D’Alessandra Y, Arcelli D, Di Donato M, et al. MicroRNA dysregulation in diabetic ischemic heart failure patients. Diabetes. 2012;61(6):1633-41. 34. Van Craenenbroeck AH, Ledeganck KJ, Van Ackeren K, Jürgens A, Hoymans VY, Fransen E, et al. Plasma levels of microRNA in chronic kidney disease: patterns in acute and chronic exercise. Am J Physiol Heart Circ Physiol. 2015;309(12):H2008-16. 35. Fernandes T, Baraúna VG, Negrão CE, Phillips MI, Oliveira EM. Aerobic exercise training promotes physiological cardiac remodeling involving a set of microRNAs. Am J Physiol Heart Circ Physiol. 2015;309(4):H543-52. 36. Chiang EP, Chiu SC, Pai MH,Wang YC,Wang FY, Kuo YH, et al. Organosulfur garlic compounds induce neovasculogenesis in human endothelial progenitor cells through a modulation of MicroRNA 221 and the PI3-K/Akt signaling pathways. J Agric Food Chem. 2013;61(20):4839-49. 37. Sorensen CM, Ding J, Zhang Q, Alquier T, Zhao R, Mueller PW, et al. Perturbations in the lipid profile of individuals with newly diagnosed type 1 diabetesmellitus: lipidomicsanalysis of aDiabetes Antibody Standardization Program sample subset. Clin Biochem. 2010;43(12):948-56. 38. Mohammadi A, Oshaghi EA. Effect of garlic on lipid profile and expression of LXR alpha in intestine and liver of hypercholesterolemic mice. J Diabetes Metab Disord. 2014;13(1):20. 39. Riedel S, Radzanowski S, Bowen TS, Werner S, Erbs S, Schuler G, et al. Exercise training improves high-density lipoprotein-mediated transcription of proangiogenic microRNA in endothelial cells. Eur J Prev Cardiol. 2015;22(7):899-903. 40. Kostrzewa-Nowak D, Nowak R, Jastrz ę bski Z, Zar ę bska A, Bichowska M, Drobnik-KozakiewiczI,etal.Effectof12-week-longaerobictrainingprogramme on body composition, aerobic capacity, complete blood count and blood lipid profile among young women. BiochemMed (Zagreb). 2015;25(1):103-13. 161