ABC | Volume 112, Nº2, February 2019

Original Article Arq Bras Cardiol. 2019; 112(2):154-162 Naderi et al Garlic and exercise increase cardiac angiogenesis 1. Osipova J, Fischer D-C, Dangwal S, Volkmann I, Widera C, Schwarz K, et al. Diabetes-associated microRNAs in pediatric patients with type 1 diabetes mellitus: a cross-sectional cohort study. J Clin Endocrinol Metab. 2014;99(9):E1661-5. 2. Tag H, Kalita P, Dwivedi P, Das AK, Namsa ND. Herbal medicines used in the treatment of diabetes mellitus in Arunachal Himalaya, northeast, India. J Ethnopharmacol. 2012;141(3):786-95. 3. Chipkin SR, Klugh SA, Chasan-Taber L. Exercise and diabetes. Cardiol Clin. 2001;19(3):489-505. 4. Huang KC, Wu WT, Yang FL, Chiu YH, Peng TC, Hsu BG, et al. Effects of freshwater clam extract supplementation on time to exhaustion, muscle damage, pro/anti-inflammatory cytokines, and liver injury in rats after exhaustive exercise. Molecules. 2013;18(4):3825-38. 5. Wu G, Rana JS, Wykrzykowska J, Du Z, Ke Q, Kang P, et al. 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The role of circulating microRNA-126 (miR-126): a novel biomarker for screening prediabetes and newly diagnosed type 2 diabetes mellitus. Int J Mol Sci. 2014;15(6):10567-77. 16. Breen EC, Johnson EC, Wagner H, Tseng HM, Sung LA, Wagner PD. Angiogenic growth factor mRNA responses in muscle to a single bout of exercise. J Appl Physiol. 1996;81(1):355-61. 17. Fasanaro P, D’Alessandra Y, Di Stefano V, Melchionna R, Romani S, Pompilio G, et al. MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3. J Biol Chem. 2008;283(23):15878-83. 18. de Amorim Miranda PH, Monteiro OM, Rossoni JV Jr., Silva ME, de Lima WG, Costa DC. Vildagliptin induces β -cell neogenesis and improves the lipid profile in a later phase of type 1 diabetes. Curr Pharm Biotechnol. 2015;16(1):60-5. 19. Naderi R, Mohaddes G, Mohammadi M, Ghaznavi R, Ghyasi R, Vatankhah AM. Voluntary exercise protects heart from oxidative stress in diabetic rats. Adv Pharm Bull. 2015;5(2):231-6. 20. Biyashev D, VeliceasaD, Topczewski J, Topczewska JM, Mizgirev I, Vinokour E, et al. miR-27b controls venous specification and tip cell fate. Blood. 2012;119(11):2679-87. 21. Lässer C, EldhM, Lötvall J. Isolation and characterization of RNA-containing exosomes. J Vis Exp. 2012(59):e3037. 22. Mirzaei Bavil F, Alipour MR, Keyhanmanesh R, Alihemmati A, Ghiyasi R, Mohaddes G. Ghrelin decreases angiogenesis, HIF-1 α and VEGF protein levels in chronic hypoxia in lung tissue of male rats. Adv Pharm Bull. 2015;5(3):315-20. 23. Khazaei M, Fallahzadeh AR, Sharifi MR, Afsharmoghaddam N, Javanmard SH, Salehi E. Effects of diabetes on myocardial capillary density and serum angiogenesis biomarkers in male rats. Clinics. 2011;66(8):1419-24. 24. Hoeben A, Landuyt B, HighleyMS,Wildiers H, VanOosteromAT, De Bruijn EA. Vascular endothelial growth factor and angiogenesis. Pharmacol Rev. 2004;56(4):549-80. 25. Chou E, Suzuma I, Way KJ, Opland D, Clermont AC, Naruse K, et al. Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic states: a possible explanation for impaired collateral formation in cardiac tissue. Circulation. 2002;105(3):373-9. References interpretation of the data: Alihemmati A; Contribue to real time PCR protocol: Khamaneh A. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding This study was funded by a grant from Drug Applied Research Center, Tabriz University of Medical Sciences. Study Association This article is part of the thesis of Doctoral submitted by Roya Naderi, from Drug Applied Research Center, Tabriz University of Medical Sciences. Ethics approval and consent to participate This study was approved by the Ethics Committee on Animal Experiments of the Tabriz University of Medical Sciences under the protocol number 91.4-2.4. 160

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