ABC | Volume 112, Nº2, February 2019

Original Article Somuncu et al Antiplatelet resistance in young MI patients Arq Bras Cardiol. 2019; 112(2):138-146 1. Gaziano JM. Global burden of cardiovascular disease. In: Braunwald E, Zipes DP, Libby P. Heart disease: a textbook of cardiovascular medicine. 6 th ed. Philadelphia: WB Saunders Company; 2001. p. 1-17. 2. Antithrombotic Trialists’ Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ. 2002;324(7329):71-86. Erratum in: BMJ. 2002;324(7330):141. 3. Perk J, De Backer G, Gohlke H, Graham I, Reiner Z, Verschuren M, et al; European Association for Cardiovascular Prevention & Rehabilitation (EACPR); ESC Committee for Practice Guidelines (CPG). European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). 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Prognostic significance of post-clopidogrel platelet reactivity assessed by a point-ofcare assay on thrombotic events after drug-eluting stent implantation. Eur Heart J. 2008;29(8):992-1000. 15. Sıller-Matula JM, Delle-Karth G, Lang IM, Neunteufl T, Kozinski M, Kubica J, et al Phenotyping vs. genotyping for prediction of clopidogrel efficacy and safety: the PEGASUS-PCI study. J Thromb Haemost. 2012;10(4):529-42. 16. Campo G, Fileti L, de Cesare N, Meliga E, Furgieri A, Russo F, et al; 3T/2R Investigators. Long-term clinical outcome based on aspirin and clopidogrel responsiveness status after elective percutaneous coronary ıntervention: a 3T/2R (tailoring treatment with tirofiban in patients showing resistance to aspirin and/or resistance to clopidogrel) trial substudy. J Am Coll Cardiol. 2010;56(18):1447-55. 17. Reny JL, Berdague P, Poncet A, Barazer I, Nolli S, Fabbro-Peray P, et al; Antiplatelet Drug Resistances and Ischemic Events (ADRIE) Study Group. Antiplatelet drug response status does not predict recurrent ıschemic events in stable cardiovascular patients Circulation. 2012;125(25):3201-3210. 18. Ritchie ME. Nuclear factor-kappa B is selectively and markedly activated in humans with unstable angina pectoris. Circulation. 1998;98(17):1707-13. 19. Burnier L, Fontana P, Kwak BR, Angelillo-Scherrer A. Cell-derived microparticles in haemostasis and vascular medicine. Thromb Haemost. 2009;101(3):439-51. 20. Gresele P, Falcinelli E, Loffredo F, Cimmino G, Corazzi T, Forte L, et al. Platelets release matrix metalloproteinase-2 in the coronary circulation of patients with acute coronary syndromes: possible role in sustained platelet activation. Eur Heart J. 2011;32(3):316-25. 21. Geisler T, Langer H, Wydymus M, Göhring K, Zürn C, Bigalke B, et al. Low response to clopidogrel is associated with cardiovascular outcome after coronary stent implantation Eur Heart J. 2006;27(20):2420-5. 22. Kastrati A, von Beckerath N, Joost A, Pogatsa-Murray G, Gorchakova O, Schomig A. Loading with 600 mg clopidogrel in patients with coronary artery disease with and without chronic clopidogrel therapy. Circulation. 2004;110(14):1916-9. References Ethics approval and consent to participate This study was approved by the Ethics Committee of the Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital under the protocol number 07.03.2014. All the procedures in this study were in accordance with the 1975 Helsinki Declaration, updated in 2013. Informed consent was obtained from all participants included in the study. 145