ABC | Volume 112, Nº1, January 2019

Original Article Barros et al Regional wall motion and cardiotoxicity prediction Arq Bras Cardiol. 2019; 112(1):50-56 Figure 2 – Roc curve of the multivariate model with and without evaluation of segmental abnormal contractility. 1.0 1.0 0.8 0.8 0.6 0.6 0.4 0.4 0.2 0.2 0.0 0.0 ROC plot Sensitivity 1 – Specificity Model without abnormal contractility Model with abnormal contractility Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding There were no external funding sources for this study. Study Association This study is not associatedwith any thesis or dissertationwork. Ethics approval and consent to participate This study was approved by the Ethics Committee of the Faculdade de Saúde e Ecologia Humana (FASEH) under the protocol number CAAE 55029916.6.0000.5101. All the procedures in this study were in accordance with the 1975 Helsinki Declaration, updated in 2013. Informed consent was obtained from all participants included in the study. 1. DeSantis CE, Ma J, Goding Sauer A, Newman LA, Jemal A. Breast cancer statistics, 2017, racial disparity in mortality by state. CA Cancer J Clin. 2017;67(6):439–48. 2. Hari KN, Benjamin F, Abigail MK, Theodore P, David H, Akinyemi B, et al. Noninvasive measures of ventricular-arterial coupling and circumferential strain predict cancer therapeutics–related cardiac dysfunction. JACC Cardiovasc Imaging. 2016;9(10):1131-41. 3. Yeh ET, Bickford CL. Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management. J Am Coll Cardiol. 2009;53(24):2231-47. 4. Slamon DJ, Leyland-Jones B, Shak S, Fuchs H, Paton V, Bajamonde A, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 2001;344(11):783-92. 5. Yeh ET, ChangH. Oncocardiology - past, present, and future. A review. JAMA Cardiol. 2016;1(9):1066-72. 6. López-Fernández T, Thavendiranathan P. Emerging cardiac imaging modalities for the early detection of cardiotoxicity due to anticancer therapies. Rev Esp Cardiol. 2017;70(6):487-95. 7. Meattini I, Curigliano G, Terziani F, Becherini C, Airoldi M, Allegrini G, et al. SAFE trial: an ongoing randomized clinical study to assess the role of cardiotoxicity prevention in breast cancer patients treated with anthracyclines with or without Trastuzumab. Med Oncol. 2017;34(5):75. 8. Reinbolt RE, Patel R, Pan X, Timmers CD, Pilarski R, Shapiro CL. et al. Risk factors for anthracycline-associated cardiotoxicity. Support Care Cancer. 2016;24(5):2173- 80. 9. Piotrowski G, Gawor R, Stasiak A, Gawor Z, Potemski P, Banach M. Cardiac complications associated with trastuzumab in the setting of adjuvant chemotherapy for breast cancer overexpressing human epidermal growth factor receptor type 2 – a prospective study. Arch Med Sci. 2012;8(2):227-35 10. Kapusta L, Thijssen J, Groot-Loonen J, Antonius T, Mulder J, Daniëls O. Tissue Doppler imaging in detection of myocardial dysfunction in survivors of childhood cancer treated with anthracyclines. Ultrasound Med Biol. 2000;26(7):1099-108. 11. Kapusta L, Groot-Loonen J, Thijssen J, de Graaf R, Daniëls O. Regional cardiac wall motion abnormalities during and shortly after anthracyclines therapy. Med Pediatr Oncol. 2003;41(5):426-35. 12. Onitilo AA, Engel JM, Stankowski RV. Cardiovascular toxicity associate with adjuvant Trastuzumab therapy: prevalence, patient characteristics, and risk factors. Ther Adv Drug Saf. 2014;5(4):154-66. References 55