ABC | Volume 112, Nº1, January 2019

Original Article Quintella et al FFR-versus angiography-guided PCI in multivessel disease Arq Bras Cardiol. 2019; 112(1):40-47 Figure 1 – Flowchart of major cardiac events (MACE) by study group. FFR: fractional flow reserve group; ANGIO: coronary angiography group. MACE n = 12 (17.4%) FFR n = 6 (17.6%) ANGIO n = 6 (17.1%) DEATHS n = 2 (5.8%) DEATHS n = 1 (2.8%) ANGINA n = 4 (11.7%) ANGINA n = 5 (14.2%) DID NOT REQUIRE ANOTHER FFR n = 2 (5.8%) CLINICAL RESTENOSIS n = 2 (5.8%) RESTENOSIS n = 4 (11.4%) LOST TO FOLLOW-UP n = 1 (2.8%) Figure 2 – Event-free survival curve (Kaplan-Meier) by group in an 18 month-period FFR: fractional flow reserve group; ANGIO: coronary angiography group. 1.00 0.75 0.50 0.25 0.00 0 0.5 1 1.5 2 Time (years) Group FFR Group ANGIO p = 0.9273 Table 3 – Characteristics of patients with compound events (Angina/Restenosis) FFR Total ANGIO Total Number of patients 1 2 3 4 1 2 3 4 5 Angina No Asymptomatic / (+) ischemia No No No No No No No No No No Vessels to be treated 2 2 2 2 8 3 2 3 2 2 12 Vessels treated 1 0 1 0 2 3 2 3 2 2 12 Control catheterization No Vessels with restenosis 1 0 1 0 2 2 3 1 (?) 1 7 Target-lesion revascularization 1 0 1 0 2 2 1 No No 1 4 FFR: fractional flow reserve group; ANGIO: coronary angiography group. particular. Although their coverage by SUS was approved in August 2014, due to their high costs, PSs are not widely provided by the system. Instead, their use is restricted to diabetic patients in whom vessels with diameter <2.5 mm and extension >18 mm is observed. 14 The choice to treat with percutaneous revascularization mutivessel diseases was grounded in studies on FS – the SYNTAX, 13 FAME 15 and FAME-2 4 studies. Data on revascularization with NPS and FFR are scarce. However, the use of FFR in multivessel diseases have been evaluated, with no difference in mortality or non-fatal infarction, despite differences in TLR. 16 This randomized, prospective study on patients with multivessel diseases referred for FFR- or angiography-guided PCI was based on FAME study, 15 using NPS though. Also, in our study, lesions with FFR > 0.75 were not treated, different 43