ABC | Volume 112, Nº1, January 2019

Original Article Dotta et al Regional QT dispersion as predictor of reperfusion Arq Bras Cardiol. 2019; 112(1):20-29 Importance and limitations So far, there are no studies specifically examining the behavior of regional QTcD in AMI patients who underwent PIS. Therefore, our data need to be further validated and replicated in future studies. Our cohort was relatively small, although larger than in previous studies. Also, advances in the methods used for the measurement of QT interval and ventricular repolarization are still needed. The lack of standardization and systematization negatively affects the accuracy in the measurement of ST-segment and T-wave in the presence of ischemia. Finally, analysis of QTcD by ECG at late follow-up could give interesting information on QTcD behavior. Conclusions Our study suggests that an increase in regional QTcD may detect adequate reperfusion 60 minutes after fibrinolysis, which could be a potential non-invasive method for evaluation of regional perfusion especially in anterior wall infarction. Author contributions Conception and design of the research: Dotta G, Póvoa RMS, Bianco HT; acquisition of data: Dotta G, SouzaMT, Pinheiro LFM, Barbosa AHP, Caixeta AM; Carvalho AC; analysis and interpretation of the data: Fonseca FAH, Izar MC, Moreira FT, Pinheiro LFM, Barbosa AHP, Póvoa RMS, Carvalho AC, Bianco HT; statistical analysis: Fonseca FAH, Izar MC, Bianco HT; writing of the manuscript: Dotta G, Souza MT, Moreira FT; critical revision of the manuscript for intellectual contente: Dotta G, Fonseca FAH, Izar MC, Moreira FT, Póvoa RMS, Carvalho AC, Bianco HT. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding There were no external funding sources for this study. Study Association This article is part of the thesis of master submitted by Gabriel Dotta, from Universidade Federal de São Paulo. Ethics approval and consent to participate This study was approved by the Ethics Committee of the Universidade Federal de São Paulo under the protocol number 2.000.970. All the procedures in this study were in accordance with the 1975 Helsinki Declaration, updated in 2013. Informed consent was obtained from all participants included in the study. 1. DanchinN, Puymirat E, Steg PG, Goldstein P, Schiele F, Belle L, et al; FAST-MI 2005 Investigators. Five-year survival in patients with ST-segment-elevation myocardial infarction according to modalities of reperfusion therapy: the French Registry on Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) 2005 Cohort. Circulation. 2014;129(16):1629-36. 2. 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