ABC | Volume 111, Nº6, December 2018

Original Article Radaelli et al Statin treatment in children: meta-analysis Arq Bras Cardiol. 2018; 111(6):810-821 Appendix V Appendix 5 – Forest plots showing the effect of statin therapy on apolipoprotein B levels. 63 44 44 24 26 35 35 90 126 126 1139 26 42 140 106 106 106 107.54 121.70 118.55 128.09 123.77 90.00 90.00 100.80 105.80 141.10 110.30 149.90 114.00 101.25 108.29 100.00 5.01 2.20 35.34 36.77 37.62 30.00 20.00 22.50 20.00 27.00 37.90 19.40 41.30 39.80 2.72 2.57 59 47 15 15 16 19 19 27 27 27 88 120 120 806 69 69 69 188.94 195.10 181.27 187.60 182.39 140.00 140.00 142.60 142.60 142.60 176.30 179.80 139.80 122.08 125.27 140.00 5.01 6.10 43.28 42.71 43.32 10.15 10.15 27.90 9.60 27.90 31.60 31.40 2.79 2.59 46.80 27.90 –50 50 0 –81.40 –73.40 –62.72 –59.51 –58.62 –50.00 –50.00 –41.80 –40.00 –36.80 –35.20 –32.30 –29.90 –25.80 –20.83 –16.98 –44.96 6.6% 6.6% 6.2% 6.2% 6.2% 6.3% 6.5% 6.1% 6.1% 6.2% 6.3% 6.6% 6.6% 100% 5.2% 5.7% 6.5% [–83.18; –79.62] [–75.18; –71.62] [–74.95; –50.49] [–71.78; –47.24] [–71.10; –46.14] [–60.24; –39.76] [–57.83; –42.17] [–55.65; –27.95] [–47.66; –32.34] [–51.58; –22.02] [–54.16; –16.24] [–45.20; –19.40] [–55.00; –4.80] [–36.32; –15.28] [–21.52; –20.14] [–17.63; –16.33] [–57.39; –32.53] Braamskamp 2015, Pitavastatin 2 mg Braamskamp 2015, Pitavastatin 1 mg Rodenburg 2006, Pravastatin 40 mg Clauss 2005, Lovastatin 20 mg McCrindle 2003,Atorvastatin 10 mg–20 mg Braamskamp 2015, Pitavastatin 4 mg Avis 2010, Rosuvastatin 5 mg de Jongh 2002, Simvastatin 20 mg de Jongh 2002, Simvastatin 10 mg de Jongh 2002, Simvastatin 40 mg Stein 1999, Lovatatin 40 mg Clauss 2005, Lovatatin 40 mg Van der Graaf 2008, Simvastatin 40 mg/Ezetimibe 10 mg Van der Graaf 2008, Simvastatin 10 mg–20 mg–40 mg/Ezetimibe 10 mg Avis 2010, Rosuvastatin 20 mg Avis 2010, Rosuvastatin 10 mg Random effects model Heterogeneity: I-squared = 99.8%, tau-squared = 607.2, p < 0.0001 Study Total Total SD SD Mean difference statins placebo Mean Mean MD W(random) 95%–Cl This is an open-access article distributed under the terms of the Creative Commons Attribution License 821