ABC | Volume 111, Nº6, December 2018

Original Article Radaelli et al Statin treatment in children: meta-analysis Arq Bras Cardiol. 2018; 111(6):810-821 Appendix III Appendix IV Appendix 3 – Forest plots showing the effect of statin therapy on low-density lipoprotein (LDL) cholesterol levels 44 42 24 26 26 18 17 18 90 35 35 63 63 63 140 106 106 106 106 126 126 1424 44 117.00 128.00 131.09 144.40 125.77 133.33 156.80 140.07 173.85 190.76 176.30 179.75 183.23 183.89 180.90 182.00 155.50 208.33 168.50 103.47 114.10 143.00 33.00 40.00 40.90 48.44 31.00 46.89 38.60 46.14 20.88 6.06 34.50 29.39 6.12 6.12 3.65 3.50 25.13 59.70 40.00 47.20 53.30 2.71 15 15 16 47 27 27 27 69 69 69 59 19 19 120 120 1053 61 88 108 6 6 6 60 227.00 227.00 228.93 239.20 214.85 227.00 215.91 239.20 208.47 239.57 255.00 239.20 239.57 242.50 239.57 236.50 237.00 206.30 252.00 209.00 134.60 144.08 16.58 16.58 8.12 61.10 54.51 15.83 55.69 61.10 61.10 54.36 56.20 55.50 3.69 3.59 36.00 44.80 4.40 4.40 4.16 7.14 7.14 7.07 4.7% 4.6% 5.1% 3.6% 4.5% 4.8% 4.5% 4.5% 4.6% 4.8% 3.8% 3.4% 4.9% 4.4% 4.9% 5.1% 5.1% 5.1% 5.1% 5.1% 100% 3.7% 3.6% [–122.86; –97.14] [–113.49; –84.51] [–100.20; –95.48] [–123.06; –66.54] [–104.91; –73.25] [–96.17; –71.83] [–98.47; –66.69] [–109.81; –54.99] [–83.95; –52.85] [–75.99; –55.45] [–66.59; –61.89] [–89.49; –36.31] [–74.18; –45.46] [–61.64; –56.90] [–67.81; –43.55] [–72.63; –38.57] [–65.20; –44.80] [–76.30; –25.30] [–46.00; –41.34] [–71.07; –9.93] [–32.05; –30.21] [–30.87; –29.09] [–76.74; –57.35] –110.00 –99.00 –97.84 –94.80 –89.08 –84.00 –82.58 –82.40 –68.40 –65.72 –64.24 –62.90 –59.82 –59.27 –55.68 –55.60 –55.00 –50.80 –43.67 –40.50 –31.13 –29.98 –67.04 –100 100 –50 50 0 Avis 2010, Rosuvastatin 20 mg Avis 2010, Rosuvastatin 10 mg McCrindle 2003,Atorvastatin 10 mg–20 mg Braamskamp 2015, Pitavastatin 4 mg Braamskamp 2015, Pitavastatin 2 mg Braamskamp 2015, Pitavastatin 1 mg de Jongh 2002, Simvastatin 40 mg de Jongh 2002, Simvastatin 20 mg de Jongh 2002, Simvastatin 10 mg Knipscheer 1996, Pravastatin 20 mg Knipscheer 1996, Pravastatin 10 mg Knipscheer 1996, Pravastatin 5 mg Rodenburg 2006, Pravastatin 40 mg Weigman 2004, Pravastatin 20 mg–40 mg Clauss 2005, Lovastatin 40 mg Clauss 2005, Lovastatin 20 mg Van der Graaf 2008, Simvastatin 40 mg/Ezetimibe 10 mg Van der Graaf 2008, Simvastatin 10 mg–20 mg–40 mg/Ezetimibe 10 mg Stein 1999, Lovastatin 20 mg Stein 1999, Lovastatin 40 mg Stein 1999, Lovastatin 10 mg Avis 2010, Rosuvastatin 5 mg Heterogeneity: I-squared = 99.5%, tau-squared = 416.6, p < 0.0001 Random effects model Study Total Total SD SD Mean difference statins placebo Mean Mean MD W(random) 95%–Cl Appendix 4 – Forest plots showing the effect of statin therapy on high-density lipoprotein (HDL) cholesterol levels. 26 27 106 106 106 106 26 63 63 18 18 1428 1053 35 44 35 44 140 63 126 126 18 90 42 49.80 50.20 48.41 48.00 47.66 49.00 44.88 50.70 49.05 46.80 46.79 50.20 50.00 55.30 49.80 46.80 47.25 50.30 48.16 50.20 54.00 51.41 9.80 10.60 10.00 12.00 0.86 0.87 16.13 12.10 10.13 1.02 0.90 10.01 13.00 13.20 11.20 1.02 1.02 10.09 15.48 11.60 11.00 16.67 27 108 120 120 15 6 16 61 59 69 19 15 6 6 19 69 60 47 27 69 88 27 52.90 52.90 48.48 48.00 47.47 48.78 44.37 49.90 48.08 45.32 45.24 48.21 48.00 52.90 47.20 44.00 44.44 47.31 44.37 45.60 48.00 44.37 10.90 10.90 9.00 3.23 0.87 0.89 9.00 10.50 14.05 1.04 1.55 13.57 3.38 10.90 8.60 1.02 1.04 15.70 9.00 9.00 9.70 3.38 –3.10 –2.70 –0.07 0.00 0.19 0.22 0.51 0.80 0.97 1.48 1.55 1.99 2.00 2.40 2.60 2.80 2.81 2.99 3.79 4.60 6.00 7.04 1.52 [–8.68; 2.48] [–8.43; 3.03] [–2.62; 2.48] [–3.98; 3.98] [–0.03; 0.41] [–9.85; 10.87] [–2.53; 4.13] [–2.87; 4.81] [1.12; 1.84] [1.08; 2.02] [–1.74; 5.72] [–2.18; 6.18] [–4.13; 8.93] [–2.76; 7.96] [2.44; 3.16] [2.44; 3.18] [–1.18; 7.16] [–6.36; 13.94] [–1.21; 10.41] [2.33; 9.67] [–3.50; 17.58] [0.75; 2.30] [0.00; 0.44] 1.6% 1.6% 5.0% 2.8% 10.9% 10.9% 0.5% 3.6% 3.1% 2.6% 1.3% 1.8% 10.7% 10.7% 2.6% 0.6% 0.5% 100% 1.5% 3.2% 3.0% 10.7% 10.6% –15 –10 –5 15 10 5 0 Avis 2010, Rosuvastatin 10 mg Avis 2010, Rosuvastatin 20 mg Avis 2010, Rosuvastatin 5 mg de Jongh 2002, Simvastatin 40 mg de Jongh 2002, Simvastatin 20 mg de Jongh 2002, Simvastatin 10 mg Stein 1999, Lovastatin 20 mg Stein 1999, Lovastatin 40 mg Stein 1999, Lovastatin 10 mg Knipscheer 1996, Pravastatin 5 mg Clauss 2005, Lovastatin 20 mg Clauss 2005, Lovastatin 40 mg Van der Graff 2008, Simvastatin 40 mg/Ezetimibe 10 mg Van der Graff 2008, Simvastatin 10 mg–20 mg–40 mg/Ezetimibe 10 mg Rodenburg 2006, Pravastatin 40 mg Knipscheer 1996, Pravastatin 10 mg Knipscheer 1996, Pravastatin 20 mg Braamskamp 2015, Pitavastatin 4 mg Braamskamp 2015, Pitavastatin 2 mg Braamskamp 2015, Pitavastatin 1 mg Weigman 2004, Pitavastatin 20 mg–40 mg McCrindle 2003,Alorvastatin 10 mg–20 mg Heterogeneity: I-squared = 93.5%, tau-squared = 1.426, p < 0.0001 Random effects model Study Total Total SD SD Mean difference statins placebo Mean Mean MD W(random) 95%–Cl 820