ABC | Volume 111, Nº6, December 2018

Original Article Einwoegerer & Domingueti Cystatin C and cardiovascular event or mortality Arq Bras Cardiol. 2018; 111(6):796-807 Registers identified in the database using MeSH descriptors. PubMed: n = 284 articles Web of Science: n = 362 articles Registers identified in the database using DeCS descriptors. Scielo: n = 1 article Total of articles n = 647 Total of articles selected after exclusion of duplicated articles n = 493 Total of articles in complete text evaluated for elegibility n = 13 Selected articles n = 12 Articles selected by metanalysis n = 2 Total de artigos duplicados n = 154 Number of articles excluded in the initial screening: n = 480 • 358 articles did not evaluate the clinical utility of the association between high levels of cystatin C and the development of acute myocardium infarction in individuals with normal renal function; • 6 articles were in languages that were not selected; • 41 did not evaluate the renal function or did not include only patients with normal renal function; • 67 articles were not observational cohort studies. • 1 abstract, • 1 comment, • 2 case-control studies, • 3 metanalyses, • 1 patent. Number of articles excluded after complete text analysis: n = 1 • Did not include only patients with normal renal function. Number of articles excluded from the metanalyses: n = 10 • 7 studies did not compare the fourth with the first quartile of cystatin C; • 3 studies did not evaluate the outcome: mortality from any cause. Figure 1 – Flow chart of the articles selected for review, according to the elegibility criteria used in the study. CHF who underwent coronary angiography, 9 with stable angina and AMI, 22 with a history of AMI that had angiographic evidence of stenosis greater than 50%, 23 or healthy elderly individuals (older than 65 years). 24 Sample size, age group and follow-up time The sample size varied from 127 to 4,663 individuals, and the sample number of 25% (n = 3) 8,20,23 of the studies ranged from 400 to 1000 individuals, 41.67% (n = 5) 7,16,19,21,22 of the studies had a sample number of less than 300 patients, and 33.33% (n = 4) 15,17,18,24 had a sample size greater than 1000. The mean age ranged from 37 to 87 years, with 41.66% (n =5) 7,8,16,18,21 of the studies evaluating both adult and elderly population (over 60 years), 50% (n = 6) 17,19,20,22-24 evaluating only the elderly population, and one study [8,33% (n = 1)] 15 analyzing only the adult population (below 60 years). The study follow-up time ranged from 6 months to 10 years, with 25% (n = 3) 7,16,22 accompanying patients for less than 15 months, 41.67% (n = 5) 8,17,19,21,23 following for 3 to 6 years, and 33.33% (n = 4) 15,18,20,24 following for a period of more than 9 years. 798