ABC | Volume 111, Nº5, November 2018

Case Report Izar et al Dercum’s disease and dyslipidemia in infanthood Arq Bras Cardiol. 2018; 111(5):755-757 1. Dercum FX. Three cases of a hitherto unclassified affection resembling in its grosser aspects obesity, but associated with special nervous symptoms – adiposis dolorosa. Am J Med Sci. 1892;104(6):521-3. 2. White WH. A case of adiposis dolorosa. Br Med J. 1899;2(2031):1533-4.1 3. Hansson E, Svensson H, Brorson H. Review of Dercum’s disease and proposal of diagnostic criteria, diagnostic methods, classification and management. Orphanet J Rare Dis. 2012 Apr 30;7:23. 4. Campen R, Mankin H, Louis DN, Hirano M, Maccollin M. Familial occurrence of adiposis dolorosa. J Am Acad Dermatol. 2001;44(1):132-6. 5. Rasmussen JC, Herbst KL, Aldrich MB, Darne CD, Tan IC, Zhu B, et al. An abnormal lymphatic phenotype is associated with subcutaneous adipose tissue deposits in Dercum’s disease. Obesity (Silver Spring). 2014;22(10):2186-92. 6. Huang LH, Elvington A, Randolph GJ. The role of the lymphatic system in cholesterol transport. Front Pharmacol. 2015 Sep 2;6:182. 7. Berntorp E, Berntorp K, BrorsonH, Frick K. Liposuction inDercum’s disease: impact on haemostatic factors associated with cardiovascular disease and insulin sensitivity. J Intern Med. 1998;243(3):197-201. 8. Asztalos BF, Tani M, Schaefer EJ. Metabolic and functional relevance of HDL subspecies. Curr Opin Lipidol. 2011;22(3):176-85. 9. Diffenderfer MR, Schaefer EJ. The composition andmetabolismof large and small LDL. Curr Opin Lipidol. 2014;25(3):221-6. 10. Enzi G, Favaretto L, Martini S, Fellin R, BaritussioA, BaggioG, et al. Metabolic abnormalities inmultiple symmetric lipomatosis: elevated lipoprotein lipase activity in adipose tissuewith hyperalphalipoproteinemia. J Lipid Res. 1983; 24(5): 566-574. 11. Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature. 2011;473(7347):317-25. 12. Fagher B, Monti M, Nilsson-Ehle P, Akesson B. Fat-cell heat production, adipose tissue fatty acids, lipoprotein lipase activity and plasma lipoproteins in adiposis dolorosa. Clin Sci (Lond). 1991;81(6):793-8. References This is an open-access article distributed under the terms of the Creative Commons Attribution License The child maintains use of the current medication for pain relief; however, there is no evidence of pain reduction in the evolution of Dercum’s disease in adults, at least in studies reporting a five-year follow-up. This case remains a challenge for physicians, the patient, and her family, who face difficulties to restore a normal life. Future research is needed to detect the etiology and evolution of Dercum’s disease from childhood to adulthood. Author contributions Conception and design of the research: Izar MCO, Fonseca HAR, Fonseca FAH; Acquisition of data: Izar MCO, Fonseca HAR, Machado VA, Ferreira CES, Fonseca FAH; Analysis and interpretation of the data: Izar MCO, França CN, Fonseca FAH; Statistical analysis: Izar MCO; Writing of the manuscript and Critical revision of the manuscript for intellectual content: Izar MCO, Fonseca HAR, França CN, Machado VA, Ferreira CES, Fonseca FAH. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding There were no external funding sources for this study. Study Association This study is not associatedwith any thesis or dissertationwork. 757