ABC | Volume 111, Nº5, November 2018

Review Article Silva et al miRNAs and cardiovascular disease Arq Bras Cardiol. 2018; 111(5):738-746 43. ThumT, Gross C, Fiedler J, Fischer T, Kissler S, BussenM, et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature. 2008;456(7224):980-4 44. Tatsuguchi M, Seok HY, Callis TE, Thomson JM, Chen JF, Newman M, et al. Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy. J Mol Cell Cardiol. 2007;42(6):1137-41. 45. Tony H, Meng K, Wu B, Yu A, Zeng Q, Yu K, et al. MicroRNA-208a Dysregulates Apoptosis Genes Expression and Promotes Cardiomyocyte Apoptosis during Ischemia and Its Silencing Improves Cardiac Function after Myocardial Infarction. Mediators Inflamm. 2015;2015 Nov 25:479123. 46. Lee SY, Lee CY, Ham O, Moon JY, Lee J, Seo HH, et al. microRNA-133a attenuates cardiomyocyte hypertrophy by targeting PKCdelta and Gq. Mol Cell Biochem. 2018;439(1-2):105-15 47. Wu Y, Wang YQ, Wang BX. [MicroRNA-133a attenuates isoproterenol- induced neonatal rat cardiomyocyte hypertrophy by downregulating L-type calciumchannelalpha1Csubunitgeneexpression.]ZhonghuaXinXueGuan Bing Za Zhi. 2013;41(6):507-13. 48. Wang YS, Zhou J, Hong K, Cheng XS, Li YG. MicroRNA-223 displays a protective role against cardiomyocyte hypertrophy by targeting cardiac troponin I-interacting kinase. Cell Physiol Biochem. 2015;35(4):1546-56. 49. Bao Q, Chen L, Li J, Zhao M, Wu S, Wu W, et al. Role of microRNA-124 in cardiomyocyte hypertrophy inducedby angiotensin II. Cell Mol Biol (Noisy- le-grand). 2017;63(4):23-27. 50. Shieh JT, Huang Y, Gilmore J, Srivastava D. ElevatedmiR-499 levels blunt the cardiac stress response. PLoS One. 2011;6(5):e19481 51. Duisters RF, Tijsen AJ, Schroen B, Leenders JJ, Lentink V, van der Made I, et al. miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs inmyocardial matrix remodeling. Circ Res. 2009;104(2):170-8, 52. 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