ABC | Volume 111, Nº4, Octuber 2018

Original Article Silva et al Predictors of family enrollment Arq Bras Cardiol. 2018; 111(4):578-584 Figure 1 – QQ Plot for the general linear model using a negative binomial distribution. 3 2 2 1 1 0 0 –1 –1 –2 –2 –3 Deviance component Theoretical Quantiles relatives in a genetic FH cascade screening program, considering clinical, demographic and socioeconomic features of ICs as the main source. Currently, for every IC with a pathogenic variant identified by molecular genetic testing, around 69.3% of eligible relatives are enrolled in our cascade screening program. For each positive IC we identified 1.8 affected relatives. 13 Table 2 – Parameters associated with relatives’ inclusion in the cascade screening according to univariate negative binomial regression analysis Predictors Estimate Std. Error p value * Age (years) 0.005 0.003 0.141 Early coronary disease † -0.024 0.143 0.867 DLCN ‡ Score (Probable) 0.117 0.415 0.777 DLCN Score (Possible) -0.158 0.600 0.792 Family history of early coronary disease 0.136 0.171 0.425 Family history of increased LDL-C levels 0.395 0.201 0.048 Educational level (Elementary) 0.460 0.326 0.159 Educational level (High School) 0.355 0.324 0.273 Educational level (College) 0.219 0.320 0.494 Employment Situation (Unemployed) -0.175 0.247 0.479 Employment Situation (Inactive) -0.204 0.150 0.174 Origin § (Rio de Janeiro) -0.751 0.400 0.060 Origin (website // ) -0.745 0.245 0.002 Current pharmacological treatment 0.179 0.190 0.346 LDL-C 0.001 0.000 0.112 * p value < 0.05. † Coronary disease in men aged < 55 years or women aged < 60 years. ‡ DLCN: Dutch Lipid Clinic Network. § IC origin was defined according to whom or from where the patient was referred to the program. // Website: by the patient itself via the program website. LDL-C: Low-density lipoprotein cholesterol. Based on ICs’ characteristics, the factor that most influences the inclusion of relatives in the program is a reported family history of dyslipidemia. High levels of LDL-C in ICs also contributed to the enrollment of relatives in the cohort, suggesting that some measure of the IC dyslipidemia severity also modulates the relatives’ willingness to enroll in disease screening. 581