ABC | Volume 111, Nº4, Octuber 2018

Original Article Yang et al ApoJ in neointimal hyperplasia Arq Bras Cardiol. 2018; 111(4):562-568 Table 1 – Serum levels of apolipoprotein J (Apo J) before and after operation in the statin intervention group Time points Pre-operation Post-operation t * p # n Apo J n Apo J 1 7 13.498 ± 3.015  7 10.317 ± 3.567 1.802 0.097 2 7 14.062 ± 4.538 7 11.516 ± 1.762 1.383 0.192 3 8 11.234 ± 2.740 8 11.117 ± 3.104 0.08 0.937 4 8 14.143 ± 4.609 8 11.205 ± 3.579 1.424 0.176 F $ 1.002 0.189 P # 0.408 0.903 * t test used to compare the differences between the two groups; $ F one-way ANOVA (analysis of variance) to compare the difference between all four groups. # p value < 0.05 was considered statistically significant. Intimal and medial membrane areas were measured using Image Pro Plus 6, and intimal/medial area ratio (intimal/medial, I/M) was used to indicate the degree of intimal hyperplasia. As shown in Table 2, the I/M was close to 0 in the control group and was significantly different from that in the model group and the intervention group at all time points (1, 2, 3 and 4 weeks). There were significant differences of I/M between different time points in the model group, and I/M reached the maximum at the fourth week. No significant difference of I/M was observed between 2, 3 and 4 weeks post-surgery in the intervention group, and I/M in the intervention group was significantly lower than that in the model group (Table 2). Taken together, our results suggest that rosuvastatin could significantly inhibit intimal hyperplasia in rats. Figure 1 – Hematoxylin-eosin (HE) staining in the control group. Upper, magnification 40×; lower, magnification 400×. Figure 2 – Hematoxylin-eosin (HE) staining in the model group and in intervention group 1 week (w), 2 weeks, 3 weeks and 4 weeks after balloon injury of rat carotid arteries; magnification 40×. 564