ABC | Volume 111, Nº4, Octuber 2018

Editorial Pagan et al Endothelial function and physical exercise Arq Bras Cardiol. 2018; 111(4):540-541 1. Kiseleva RY, Glassman PM, Greineder CF, Hood ED, Shuvaev VV, Muzykantov VR. Targeting therapeutics to endothelium: Are we there yet? Drug Deliv Transl Res. 2018;8(4):883-902. 2. Persson PB. The multiple functions of the endothelium: More than just wallpaper. Acta Physiol. 2015;(4)213:747-9. 3. Rajendran P, Rengarajan T, Thangavel J, Nishigaki Y, Sakthisekaran D, Sethi G, et al. The vascular endothelium and human diseases. Int J Biol Sci. 2013;9(10):1057-69. 4. Rodrigues AC, Natali AJ, Cunha DNQD, Costa AJLD, Moura AG, Araújo Carneiro-Júnior M, et al. Moderate continuous aerobic exercise training improves cardiomyocyte contractility in β 1 adrenergic receptor knockout mice. Arq Bras Cardiol. 2018;110(3):256-62. 5. Winter SCN, Macedo RM, Francisco JC, Santos PC, Lopes APS, Meira LF, et al. Impact of a high-intensity training on ventricular function in rats after acute myocardial infarction. Arq Bras Cardiol. 2018;110(4):373-80. 6. LemosMP, MotaGRD, MarocoloM, Sordi CC, Chriguer RS, BarbosaNetoO. Exercise training attenuates sympathetic activity and improvesmorphometry of splenic arterioles in spontaneously hipertensive rats. Arq Bras Cardiol. 2018;110(3):263-9. 7. MartinezJE,TaipeiroEF,ChiesAB.Effectsofcontinuousandaccumulatedexercise onendothelialfunction inrataorta.ArqBrasCardiol.2017;108(4):315-22. 8. Gomes MFP, Borges ME, Rossi VA, Moura EOC, Medeiros A. The effect of physical resistance training on baroreflex sensitivity of hypertensive rats. Arq Bras Cardiol. 2017;108(6):539-45. 9. Gomes MJ, Martinez PF, Campos DHS, Pagan LU, Bonomo C, Lima AR, et al. Beneficial effects of physical exercise on functional capacity and skeletal muscle oxidative stress in rats with aortic stenosis-induced heart failure. Oxid Med Cell Longev. 2016;2016:8695716. 10. Pagan LU, Damatto RL, Cezar MD, Lima AR, Bonomo C, Campos DH, et al. Long-term low intensity physical exercise attenuates heart failure development in aging spontaneously hypertensive rats. Cell Physiol Biochem. 2015;36(1):61-74. 11. Gomes MJ, Martinez PF, Pagan LU, Damatto RL, Cezar MD, Lima AR, et al. Skeletal muscle aging: Influence of oxidative stress and physical exercise. Oncotarget. 2017;8(12):20428-40. 12. Ghorbanzadeh V, Mohammadi M, Dariushnejad H, Abhari A, Chodari L, Mohaddes G. Cardioprotective effect of crocin combined with voluntary exercise in rat: Role of mir-126 andmir-210 in heart angiogenesis. Arq Bras Cardiol. 2017;109(1):54-62. 13. Durand MJ, Gutterman DD. Exercise and vascular function: How much is too much? Can J Physiol Pharmacol. 2014;92(7):551-7. 14. MotaMM, Silva TLTBD, Macedo FN, Mesquita TRR, Quintans LJJ, Santana- Filho VJ, et al. Effects of a single bout of resistance exercise in different volumes on endothelium adaptations in healthy animals. Arq Bras Cardiol. 2017;108(5):436-42. 15. Faria TO, Angeli JK, Mello LGM, Pinto GC, Stefanon I, Vassallo DV, et al. A single resistance exercise session improves aortic endothelial function in hypertensive rats. Arq Bras Cardiol. 2017;108(3):228-36. References This is an open-access article distributed under the terms of the Creative Commons Attribution License These experimental studies suggest that the practice of physical exercises plays a relevant role in the treatment of endothelial dysfunction. However, additional studies are needed to establish the best type, intensity and duration of exercise, and to allow more efficient prescribing. Acknowledgments Funding by the National Council for Scientific and Technological Development (CNPq) (Proc. No. 308674 / 2015-4) and São Paulo Research Foundation (FAPESP) (Proc. N°. 2014 / 23592-3 and 2014 / 00747-1). 541