ABC | Volume 111, Nº3, September 2018

Original Article Pinotti et al Fasting/refeeding cycles and myocardial remodeling Arq Bras Cardiol. 2018; 111(3):400-409 11. Gut AL, Okoshi MP, Padovani CR, Aragon FF, Cicogna AC. Myocardial dysfunction induced by food restriction is related to calcium cycling and beta-adrenergic system changes. Nutr Res. 2003;23(7):911-9. 12. Okoshi MP, Okoshi K, Pai VD, Pai-Silva MD, Matsubara LS, Cicogna AC. Mechanical, biochemical, and morphological changes in the heart from chronic food-restricted rats. Can J Physiol Pharmacol. 2001;79(9):754-60. 13. Ahmet I, Wan R, Mattson M, Lakatta EG, Talan MI. Chronic alternate-day fasting results in reduced diastolic compliance and diminished systolic reserve in rats. J Card Fail. 2010;16(10): 843-53. 14. Longo VD, Mattson PM. Fasting: molecular mechanisms and clinical applications. Cell Metab. 2014;19(2):181-92. 15. FannDY, Ng GY, Poh L, ArumugamTV. Positive effects of intermittent fasting in ischemic stroke. Exp Gerontol. 2017 Mar;89:93-102. 16. 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Cas Lek Cesk. 2016;155(2):34-40. 21. Young EA, Cantu TL, Harris MM. Gastrointestinal and cardiac response to refeedingafter low-caloriesemistarvation.AmJClinNutr.1989;50(5):922-9. 22. Ameredes BT, Daood MJ, Watchko JF. Refeeding reverses cardiac myosin shifts induced by undernutrition in aged rats: modulation by growth hormone. J Mol Cell Cardiol. 1998;30(8):1525-33. 23. Freund HR, Holroyde J. Cardiac function during protein malnutrition and refeeding in the isolated rat heart. JPEN J Parenter Enteral Nutr. 1986;10(5):470-3. 24. Pinotti MF, Leopoldo AS, Silva MD, Sugizaki MM, do Nascimento AF, Lima-Leopoldo AP, et al. A comparative study of myocardial function and morphology during fasting/refeeding and food restriction in rats. Cardiovasc Pathol. 2010;19(5):175-82. 25. Pinotti MF, Silva MD, Sugizaki MM, Diniz YS, Sant’Ana LS, Aragon FF, et al. Effect of unsaturated fatty acids on myocardial performance, metabolism and morphology. Braz J Med Biol Res. 2006;39(2):305-12. 26. 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Mattson MP, Longo VD, Harvie M. Impact of intermittent fasting on health and disease processes. Ageing Res Rev. 2017 Oct;39:46-58. 33. Carvalho RF, Castan EP, Coelho CA, Lopes FS, Almeida FL, Michelin A, et al. Heart failure increases atrogin-1 and MuRF1 gene expression in skeletal muscle with fiber type-specific atrophy. J Mol Histol. 2010;41(1):81-7. 34. Razeghi P, Baskin KK, Sharma S, Young ME, Stepkowski S, Essop MF, et al. Atrophy, hypertrophy, and hypoxemia induce transcriptional regulators of the ubiquitin proteasome system in the rat heart. Biochem Biophys Res Commun. 2006;342(2):361-4. 35. Gut AL, Sugizaki MM, Okoshi MP, Carvalho RF, Pai-Silva MD, Aragon FF, et al. Food restriction impairs myocardial inotropic response to calcium and beta-adrenergic stimulation in spontaneously hipertensive rats. Nutr Res. 2008;28(10):722-7. 36. Souza Junior AL, Malfitano C, Figueroa D, de Souza LE, Ignotti E, Irigoyen MC, et al. 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