ABC | Volume 111, Nº2, August 2018

Original Article Duarte et al Iron impact in acute coronary syndrome Arq Bras Cardiol. 2018; 111(2):144-150 Table 1 – Basal and clinical characteristics, according to iron and ferritin tertiles Basal characteristics Population n = 280 1 st iron tertile (≤ 40 mcg/dL) 2 nd iron tertile (> 40 or ≤ 67 mcg/dL) 3 rd iron tertile (> 67 mcg/dL) p value 1 st ferritin tertile (≤ 110 ng/mL) 2 nd ferritin tertile (>110 or ≤ 219 ng/mL) 3 rd ferritin tertile (> 219 ng/mL) p value Age, years 68 ± 13 69 ± 15 69 ± 12 67 ± 13 < 0.001 73 ± 12 66 ± 14 67 ± 13 0.001 Male gender 204 (73) 63 (23) 73 (26) 68 (24) 0.12 53 (19) 68 (24) 78 (28) 0.12 Personal history SAH 186 (66.4) 56 (20) 70 (25) 60 (21) 0.12 69 (25) 58 (21) 57 (20) 0.12 Diabetes mellitus 90 (32) 36 (13) 30 (11) 24 (9) 0.21 32 (11.4) 32 (11.4) 26 (9.3) 0.69 Dyslipidemia 140 (50) 37 (13) 59 (21) 44 (16) 0.87 46 (16) 49 (18) 43 (15) 0.34 History of AMI 44 (16) 10 (3.6) 18 (6.4) 16 (6) 0.21 18 (6.4) 15 (5.3) 11 (4) 0.42 History of HF 9 (3.2) 2 (0.7) 5 (1.8) 2 (0.7) 0.34 2 (0.7) 3 (1.1) 4 (1.4) 0.68 Renal failure 21 (8) 8 (3) 7 (2.5) 6 (2) 0.8 9 (3.2) 6 (2) 6 (2) 0.6 PAD 11 (4) 3 (1) 3 (1) 5 (1.8) 0.7 8 (3) 3 (1) 0 0.7 ACS type Unstable angina 12 (4.3) 3 (1) 2 (0.7) 7 (2.5) 0.21 7 (2.5) 3 (1) 2 (0.7) 0.85 STEMI 125 (45) 50 (18) 43 (15.3) 32 (11) 35 (13) 41 (15) 45 (16) NSTEMI 122 (44) 36 (13) 41 (15) 45 (16) 41 (15) 40 (14) 40 (14) Undetermined AMI 21 (8) 6 (2.1) 6 (2.1) 9 (3.2) 9 (3.2) 10 (4) 2 (0.7) Results expressed as n (%) or mean ± median. SAH: systemic arterial hypertension; AMI: acute myocardial infarction; HF: heart failure; PAD: peripheral arterial disease; ACS: acute coronary syndrome; STEMI: ST-segment elevation myocardial infarction; NSTEMI: Non-ST-segment elevation myocardial infarction. Table 2 – Clinical and laboratory characteristics, according to iron and ferritin tertiles Clinical presentation Population n = 280 1 st iron tertile (≤ 40 mcg/dL) 2 nd iron tertile (> 40 or ≤ 67 mcg/dL) 3 rd iron tertile (> 67 mcg/dL) p value 1 st ferritin tertile (≤ 110 ng/mL) 2 nd ferritin tertile (>110 or ≤ 219 ng/mL) 3 rd ferritin tertile (> 219 ng/mL) p value Killip Class I 244 (87) 74 (27) 83 (30) 87 (31) 0.12 73 (26) 88 (31.4) 78 (28) 0.23 Killip Class II 18 (6.4) 11 (4) 4 (1.4) 3 (1) 14 (5) 2 (0.7) 2 (0.7) Killip Class III 11 (3.9) 4 (1.4) 4 (1.4) 3 (1) 3 (1) 2 (0.7) 6 (2.1) Killip Class IV 7 (2.5) 6 (2.1) 4 (1.4) 0 2 (0.7) 2 (0.7) 3 (1) Ejection fraction classification LVEF > 50% 157 (69) 42 (15) 58 (21) 57 (20) 0.08 43 (15) 59 (21) 54 (19) 0.7 LVEF 41-50% 23 (10) 16 (6) 3 (1) 4 (1.4) 7 (2.5) 9 (3) 7 (2.5) LVEF 30-40% 38 (17) 16 (6) 14 (5) 8 (3) 16 (6) 8 (3) 11 (4) LVEF < 30% 11 (5) 4 (1.4) 4 (1.4) 3 (1) 6 (2.1) 2 (0.7) 3 (1) Laboratory assessment Creatinine, mg/dL 1.08 ± 0.9 1.2 ± 1.2 1.05 ± 0.6 0.9± 1.8 0.9 1.1 ± 0.7 1 ± 0.6 1.1 ± 1.2 0.8 BNP, pg/mL 331.6 ± 499 567 ± 712 266 ± 371 180 ± 212 < 0.001 488 ± 684 204 ± 270 346 ± 427 0.001 Hemoglobin, g/dL 13.1 ± 2 11.8 ± 2.2 13.4 ± 2 14 ± 16 < 0.001 12 ± 2.2 14 ± 1.7 14 ± 2 <0.001 Results expressed as n (%) or mean ± median. LVEF: left ventricular ejection fraction; BNP: brain natriuretic peptide. 146