ABC | Volume 111, Nº1, July 2018

Original Article Bassi et al T2DM and HTN on HRV and cardiorespiratory status Arq Bras Cardiol. 2018; 111(1):64-72 Relevance of the present study This is the first study, to our knowledge, to assess linear and nonlinear HRV dynamics in the coexistence of HTN and T2DM. Previous studies have reported cardiac autonomic dysfunction in diabetic subjects and in hypertensive subjects; 30 this study is relevant, as it showed that there is a simultaneous influence of HTN and DMT2 on nonlinear HRV indexes and on novel CPET derived parameters. In addition, VP and CP, indices that combine parameters of CPET with systemic hemodynamics during exercise represent important Figure 2 – Significant and inverse relationship between SD1 and (A) VP (A) and between SD1 and (B) V E /VCO 2 slope in response to peak intensity exercise in patients with diabetes mellitus type 2 and hypertension (TD2DM+HTN) (●) and in patients with type 2 diabetes mellitus (TD2DM) (°). (A) (B) 40 40 30 30 20 20 10 10 0 .0 20 25 30 35 40 1.0 2.0 3.0 4.0 VP (mmHg) VE/VCO2 Slope SD1 SD1 p ≤ 0.03 R = – 0.32 R 2 = 0.10 p ≤ 0.05 R = – 0.28 R 2 = 0.08 T2DM T2DM+HTN Figure 1 – Significant and inverse relationship of approximate entropy (ApEn) with ventilatory power (VP) (A) and minute ventilation/carbon dioxide production ratio (V E /VCO 2 )slope (B) in response to peak intensity exercise in patients with type 2 diabetes. (A) (B) 1.2 1.2 1.1 1.1 1.0 1.0 .9 .9 .8 .8 .7 1.0 20 25 30 35 40 1.3 1.5 1.8 2.0 2.3 VP (mmHg) VE/VCO2 Slope Apen Apen p ≤ 0.02 R = – 0.48 R 2 = 0.24 p ≤ 0.05 R = – 0.40 R 2 = 0.16 69