ABC | Volume 111, Nº1, July 2018

Original Article Pereira et al. Genes and coronary artery disease risk Arq Bras Cardiol. 2018; 111(1):50-61 This is an open-access article distributed under the terms of the Creative Commons Attribution License 20. Deloukas P, Kanoni S,Willenborg C, Farrall M, Assimes TL, Thompson JR, et al; CARDIoGRAMplusC4DConsortium.Large-scaleassociationanalysisidentifies new risk loci for coronary artery disease. Nat Genet. 2013;45(1):25-33. 21. RobertsR.Geneticsofcoronaryarterydisease.CircRes.2014;114(12):1890-903. 22. Ripatti S, Tikkanen E, Orho-Melander M, Havulinna AS, Silander K, Sharma A,etal.Amultilocusgeneticriskscoreforcoronaryheartdisease:case-control and prospective cohort analyses. Lancet. 2010;376(9750):1393-400. 23. Vaarhorst AA, Lu Y, Heijmans BT, Dollé ME, Böhringer S, Putter H, et al. Literature-based genetic risk scores for coronary heart disease: the Cardiovascular Registry Maastricht (CAREMA) prospective cohort study. Circ Cardiovasc Genet. 2012;5(2):202-9. 24. Thanassoulis G, Peloso GM, Pencina MJ, Hoffman U, Fox CS, Cupples LA. A genetic risk score is associated with incident cardiovascular disease and coronary artery calcium: the Framingham Heart Study. Circ Cardiovasc Genet. 2012;5(1):113-21. 25. Jansen H, Loley C, Lieb W, Pencina MJ, Nelson CP, Kathiresan S, et al; CARDIoGRAM consortium. Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk. Atherosclerosis. 2015;241(2):419-26. 26. Webb TR, Erdmann J, Stirrups KE, Stitziel NO, Masca NG, Jansen H, et al. Systematic evaluation of pleiotropy identifies 6 further loci associated with coronary artery disease. J Am Coll Cardiol. 2017;69(7):823-36. 59