ABC | Volume 111, Nº1, July 2018

Original Article Kalkan et al Adropin and Irisin Arq Bras Cardiol. 2018; 111(1):39-47 Table 1 – Baseline demographic, clinical and laboratory characteristics of the study groups CHF without cachexia (n = 42) CHF with cachexia (n = 44) p value Age, (years), mean (SD) 61.0 (16.47) 65.4 (11.18) 0.179 Male Gender, n (%) 27 (64.3) 27 (61.4) 0.779 NYHA, class I-II, n (%) 30 (60) 20 (40) 0.015 class III-IV, n (%) 12 (33.3) 24 (66.7) Ischemic Etiology, n (%) 28 (66.7) 26 (59.1) 0.468 LVEF, n (%) Anthropometric parameters 31.7 (7.89) 31.4 (6.71) 0.882 BMI (kg/m 2 ), mean (SD) 29.2 (4.25) 19.9 (1.12) < 0.001 TST (mm), mean (SD) 17.9 (3) 13.4 (2.45) < 0.001 AMA (cm 2 ), mean (SD) 35.9 (8.7) 24.4 (4.03) < 0001 Comorbidities Hypertension, n (%) 27 (64.3) 26 (59) 0.620 Diabetes mellitus, n (%) 18 (42.9) 26 (59.1) 0.290 Chronic renal failure, n (%) 14 (33.3) 15 (34.1) 0.941 Chronic obstructive lung disease, n (%) 8 (19) 8 (18.2) 0.918 Laboratory parameters Glucose (mg/dL), mean (SD) 155.3 (78.5) 150.3 (48.3) 0.685 Creatinine (mg/dL), mean (SD) 1.15 (0.63) 1.19 (0.8) 0.997 Hemoglobine (%), mean (SD) 11.9 (1.38) 11.3 (1.34) 0.049 WBC (mg/L), mean (SD) 8.35 (4.2) 8.45 (3.98) 0.742 Adropin (ng/L) median (IQR) 213.7 (203.1-251.3) 286.1 (231.3-404.0) < 0.001* Irisin ( μg/mL), median (IQR) 2.1 (1.8-2.4) 2.6 (2.2-4.4) 0.001* BNP (pg/mL), median (IQR) 698.0 (340.0-1517.0) 1408.5 (725.0-4041.0) 0.001* Albumin (mg/dL), mean (SD) 3.3 (0.46) 3.12 (0.36) 0.041 Sodium (mEq/L), mean (SD) 138.7 (10.1) 135.7 (9.7) 0.136 Total cholesterol (mg/dL), mean (SD) 164.5 (44.1) 153.2 (44.4) 0.240 LDL-cholesterol (mg/dL), mean (SD) 108.4 (40.5) 101.1 (32.7) 0.366 HDL-cholesterol (mg/dL), mean (SD) 36.2 (10.4) 31 (9.1) 0.015 Triglyceride (mg/dL), mean (SD) Drug therapy 134.2 (50) 122.3 (56) 0.302 Furosemide, n (%) 35 (83.3) 40 (90.9) 0.293 ACE-i/ARB, n (%) 20 (47.6) / 11 (26.2) 28 (63.6) / 11 (25.2) 0.136 Spironolactone, n (%) 26 (61.9) 30 (68.2) 0.542 Statin, n (%) 16 (38.1) 18 (40.9) 0.790 Beta-blocker, n (%) 33 (78.6) 39 (88.6) 0.206 Ivabradine, n (%) 15 (25) 11 (25) 0.289 CRT, n (%) 9 (21.4) 6 (13.6) 0.341 n: number; SD: standard deviation; IQR: interquartile range; NYHA: New York Heart Association; LVEF: left ventricular ejection fraction; BMI: body mass index; TST: triceps skinfold thickness; AMA: arm muscle area; WBC: white blood cell; BNP: brain natriuretic peptide; LDL: low-density lipoprotein; HDL: high-density lipoprotein; ACE-i: angiotensin-converting-enzyme inhibitor; ARB: angiotensin receptor blocker; CRT: cardiac resynchronization therapy. *: mann-whitney u-test. 42