ABC | Volume 110, Nº6, June 2018

Original Article Zhen et al AAC leads to obvious CH using 0.45 mm needle Arq Bras Cardiol. 2018; 110(6):568-576 10. Karimian S, Stein J, Bauer B, Teupe C. Impact of severe obesity and weight loss on systolic left ventricular function and morphology: assessment by 2-dimensional speckle-tracking echocardiography. J Obes. 2016;2016:2732613. doi: 10.1155/2016/2732613. 11. Elliott P, McKenna WJ. Hypertrophic cardiomyopathy. Lancet. 2004;363(9424):1881-91. doi: 10.1016/S0140-6736(04)16358-7. 12. Zhao B, Wang S, Chen J, Ji Y, Wang J, Tian X, et al. Echocardiographic characterization of hypertrophic cardiomyopathy in Chinese patients with myosin-binding protein C3 mutations. Exp Ther Med. 2017;13(3):995- 1002. doi: 10.3892/etm.2017.4089. 13. Hunter JJ, Chien KR. Signaling pathways for cardiac hypertrophy and failure. N Engl J Med. 1999;341(17):1276-83. doi: 10.1056/ NEJM199910213411706. 14. Huang CK, Chen BY, Guo A, Chen R, Zhu YQ, Kutschke W, et al. Sildenafil ameliorates left ventricular T-tubule remodeling in a pressure overload- inducedmurine heart failuremodel. Acta Pharmacol Sin. 2016;37(4):473- 82. doi: 10.1038/aps.2016.13. 15. Tsotetsi OJ, Woodiwiss AJ, Netjhardt M, Qubu D, Brooksbank R, Norton GR. Attenuation of cardiac failure, dilatation, damage, and detrimental interstitial remodeling without regression of hypertrophy in hypertensive rats. Hypertension. 2001;38(4):846-51. doi: https://doi.org/10.1161/ hy1001.092649. 16. Kuwahara F, Kai H, Tokuda K, Kai M, Takeshita A, Egashira K, et al. Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats. Circulation. 2002;106(1):130-5. doi: https://doi.org/10.1161/01. CIR.0000020689.12472.E0. 17. Minior VK, Levine B, Ferber A, Guller S, Divon MY. Nucleated red blood cells as a marker of acute and chronic fetal hypoxia in a rat model. Rambam Maimonides Med J. 2017;8(2). doi: 10.5041/RMMJ.10302. 575