ABC | Volume 110, Nº6, June 2018

Original Article Oishi et al Endothelial dysfunction and blood pressure in rats Arq Bras Cardiol. 2018; 110(6):558-567 31. Stapleton PA, James ME, Goodwill AG, Frisbee JC. Obesity and vascular dysfunction. Pathophysioloy. 2008;15(2):79-89. doi: 10.1016/j. pathophys.2008.04.007. 32. Prieto D, Contreras C, Sánchez A. Endothelial dysfunction, obesity and insulin resistance. Curr Vasc Pharmacol. 2014;12(3):412-26. doi: 10.2174 /1570161112666140423221008. 33. Garrison RJ, Kannel WB, Stokes J 3rd, Castelli WP. Incidence and precursors of hypertension in young adults: the FraminghamOffspring Study. PrevMed. 1987;16(2):235-51. doi: https://doi.org/10.1016/0091-7435 (87)90087-9. 34. Boustany CN, Bharadwaj K, Daugherty A, Brown DR, Randall DC, Cassis LA. Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension. Am J Physiol Regul Integr Comp Physiol. 2004;287(4):R943-9. doi: 10.1152/ajpregu.00265.2004. 35. Arribas SM, Hinek A, Gonzalez MC. Elastic fibres and vascular structure in hypertension. Pharmacol Ther. 2006;111(3):771-91. doi: 10.1016/j. pharmthera.2005.12.003. 36. Chen J, Wang S, Luo M, Zhang Z, Dai X, Kong M, et al. Zinc deficiency worsens and supplementation prevents high-fat diet induced vascular inflammation, oxidative stress, and pathological remodeling. Toxicol Sci. 2016;153(1):124-36. doi: 10.1093/toxsci/kfw110. 37. Martínez-Martínez E, MianaM, Jurado-López R, BartoloméMV, SouzaNeto FV, Salaices M, et al. The potential role of leptin in the vascular remodeling associated with obesity. Int J Obes (Lond). 2014;38(12):1565-72. doi: 10.1038/ijo.2014.37. 38. Schulz E, Gori T, Münzel T. Oxidative stress and endothelial dysfunction in hypertension. Hypertens Res. 2011;34(6):665-73. doi:10.1038/hr.2011.39 39. Vincent HK, Innes KE, Vincent KR. Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity. Diabetes Obes.Metab.2007;9(6):813-39.doi:10.1111/j.1463-1326.2007.00692.x. 40. Victor VM, Apostolova N, Herance R, Hernandez-Mijares A, Rocha M. Oxidative stress and mitochondrial dysfunction in atherosclerosis: mitochondria-targeted antioxidants as potential therapy. Curr Med Chem. 2009;16(35):4654-67. doi: 10.2174/092986709789878265. This is an open-access article distributed under the terms of the Creative Commons Attribution License 567

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