ABC | Volume 110, Nº6, June 2018

Original Article Oishi et al Endothelial dysfunction and blood pressure in rats Arq Bras Cardiol. 2018; 110(6):558-567 1. Beleigoli AM, Boersma E, DinizMD, Lima-CostaMF, Ribeiro AL. Overweight and class I obesity are associated with lower 10-year risk of mortality in Brazilian older adults: the Bambuí Cohort Study of Ageing. PLoS One. 2012;7(12):e52111. doi: 10.1371/journal.pone.0052111. 2. FieldAE, Coakley EH, Must A, Spadano JL, LairdMA, DietzWH, et al. Impact of overweight on the risk of developing common chronic diseases during a 10 year period. Arch Intern Med. 2001;161(13):1581-6. doi:10.1001/ archinte.161.13.1581. 3. IantornoM, Campia U, Di Daniele N, Nistico S, Forleo GB, Cardillo C, et al. Obesity, inflammation and endothelial dysfunction. J Biol Regul Homeost Agents. 2014;28(2):169-76. PMID: 25001649. 4. WorldHealthOrganization. (WHO) Cardiovascular diseases. [Cited in 2016 Feb 10]. Available from: http://www.who.int/cardiovasculardiseases/en 5. Davel AP, Wenceslau CF, Akamine EH, Xavier FE, Couto, GK, Oliveira HT, et al. Endothelial dysfunction in cardiovascular and endocrine-metabolic diseases: an update. Braz J Med Biol Res. 2011;44(9):920-32. doi: http:// dx.doi.org/10.1590/S0100-879X2011007500104. 6. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980;288(5789):373-6. PMID: 6253831. 7. VanhouttePM.Theendothelium–modulatorofvascularsmooth-muscletone. N Engl J Med. 1988;319(8):512-3. doi: 10.1056/NEJM198808253190809. 8. Furchgott RF, Vanhoutte PM. Endothelium-derived relaxing and contracting factors. FASEB J. 1989;3(9):2007-18. PMID: 2545495. 9. Costa RR, Villela NR, Souza MG, Boa BC, Cyrino FZ, Silva SV, et al. High fat diet induces central obesity, insulin resistance and microvascular dysfunction in hamsters.Microvasc Res. 2011;82(3):416-22. doi: 10.1016/j. mvr.2011.08.007. 10. Kurtel H, Rodrigues SF, Yilmas CE, Yildirim A, Granger DN. Impaired vasomotor function induced by combination of hypertension and hypercholesterolemia. J Am Soc Hypertens. 2013;7(1):14-23. doi:10.10.16/j.jash.2012.11.005. 11. Estadella D, Oyama LM, Bueno AA, Habitante CA, Souza GI, Ribeiro EB, et al. A palatable hyperlipidic diet causes obesity and affects brain glucose metabolism in rats. Lipids Health Dis. 2011;Sep 23;10:168. doi: 10.1186/1476-511X-10-168. 12. Rodrigues GJ, Pereira AC, Vercesi JA, Lima RG, Silva RS, Bendhack LM. Long-lasting hypotensive effect in renal hypertensive rats induced by nitric oxide released from a ruthenium complex. J Cardiovasc Pharmacol. 2012;60(2):193-8. doi: 10.1097/FJC.0b013e31825bacc4. 13. Oishi JC, Buzinnari TC, Pestana CR, De Moraes TF, Vatanabe IP, Wink DA, et al. In vitro treatment with cis-[(Ru(H-dcbpy-)2(Cl)(NO)]) improves the endothelial function in aortic rings with endothelial dysfunction. J Pharm Pharm Sci. 2015;18(5):696-704. PMID: 26670366. 14. Jiang ZY, Woollard AC, Wolff S. Lipid hydroperoxide measurement by oxidation of Fe2 + in the presence of xylenol orange. Comparison with the TBA Assay and a lodometric Method. Lipids. 1991;26(10)853-6. PMID: 1795606. 15. PereiraFH,BatalhãoME,CárnioEV.Correlationbetweenbodytemperature, blood pressure and plasmatic nitric oxide in septic patients. Rev Lat Am Enfermagem. 2014;22(1):123-8. doi: 10.1590/0104-1169.2896.2392. 16. Coura MA, Pacheco ME, Simões HF, Moraes JF, Campbell CS. Estudo morfoquantitativo da parede da aorta de ratos wistar idosos treinados com exercício aeróbio. Motri. 2012;8(4):71-9. doi: http://dx.doi.org/10.6063/ motricidade.8(4).1554. 17. Huang PL. eNOS, metabolic syndrome and cardiovascular disease. Trends Endocrinol Metab. 2009;20(6):295-302. doi: 10.1016/j.tem.2009.03.005. 18. Gomez-Ambrosi J, Silva C, Galofre JC, Escalada J, Santos S, Millán D, et al. Body mass index classification misses subjects with increased cardiometabolic risk factors related to elevated adiposity. Int J Obes. (Lond). 2012;36(2):286-94. doi: 10.1038/ijo.2011.100. 19. TchernofA,DespresJP.Pathophysiologyofhumanvisceralobesity:anupdate. Physiol Rev. 2013;93(1):359-404. doi: 10.1152/physrev.00033.2011. 20. Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol. 2011;29:415-45. doi: 10.1146/annurev- immunol-031210-101322. 21. Jung UJ, Choi MS. Obesity and Its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. J Mol Sci. 2014;15(4):6184-223. doi:10.3390/ijms15046184. 22. LiFY,LamKS,XuA.Therapeuticperspectivesfora diponectin:anupdate.Curr Med Chem. 2012;19(32):5513-23. doi: 10.2174/092986712803833173. 23. Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature. 2006;444(7121):875-80. doi: 10.1038/ nature05487. 24. Barbosa-da-Silva S, Fraulob-Aquino JC, Lopes JR, Mandarim-de-Lacerda CA, Aguila MB. Weight cycling enhances adipose tissue inflammatory responses in male mice. PLoS One. 2012;7(7):e39837. doi: 10.1371/ journal.pone.0039837. 25. Carvalho KM, Marinho Filho JD, de Melo TS, Araújo AJ, Quetz Jda S, da Cunha Mdo P, et al. The resin from protium heptaphyllum prevents high-fat diet-induced obesity in mice: scientific evidence and potential mechanisms. Evid Based Complement Alternat Med. 2015;2015:106157. doi: 10.1155/2015/106157. 26. Chantemele EJ, Stepp DW. Influence of obesity and metabolic dysfunction on the endothelial control in the coronary circulation. Mol Cell Cardiol. 2012;52(4):840-7. doi:10.1016/j.yjmcc.2011.08.018. 27. Bray GA. Medical consequence of obesity. J Clin Endocrinol Metab. 2004;89(6):2583-9. doi: 10.1210/jc.2004-0535. 28. De Kreutzenberg SV, Crepaldi C, Marchetto S, Calò L, Tiengo A, Del Prato S, et al. Plasma free fatty acids and endothelium-dependent vasodilation: effect of chain-length and cyclooxygenase inhibition. J Clin Endocrinol Metab. 2000;85(2):793-8. doi: 10.1210/jcem.85.2.6352. 29. Boustany-KaryCM, GongM,AkersWS,GuoZ,CassisLA.Enhancedvascular contractility and diminished coronary artery flow in rats made hypertensive from diet-induced obesity. Int J Obes (Lond). 2007;31(11):1652-9. doi: 10.1038/sj.ijo.0803426. 30. Kobayasi R, Akamine EH, Davel AP, Rodrigues MA, Carvalho CR, Rossoni LV. Oxidative stress and inflammatory mediators contribute to endothelial dysfunction in high-fat diet-induced obesity in mice. J Hypertens. 2010;28(10):2111-9 doi: 10.1097/HJH.0b013e32833ca68c. References Study Association This article is part of the thesis of Post Doctoral submitted by Jorge Camargo Oishi, from Universidade Federal de São Carlos. Ethics approval and consent to participate This study was approved by the Ethics Committee on Animal Experiments of Universidade Federal de São Carlos under the protocol number 026/2013. 566

RkJQdWJsaXNoZXIy MjM4Mjg=