ABC | Volume 110, Nº2, February 2018

Original Article Gripp et al Global Longitudinal Strain Accuracy for Cardiotoxicity Arq Bras Cardiol. 2018; 110(2):140-150 Figure 1 – Bland-Altman plots showing interobserver analysis of left ventricular global longitudinal strain (LV GLS), right ventricular (RV) strain and right ventricular free wall (RVFW) strain in A, B and C, respectively. 2.00 1.00 .00 –1.00 –2.00 A B C –22.50 –20.00 –20.00 –20.00 –25.00 –25.00 –30.00 –30.00 –35.00 –17.50 –15.00 –15.00 –15.00 –12.50 Meanof the interobserverLVGLS MeanRV strain MeanRVFWstrain Difference inLVGLSmeasures 2.00 1.00 .00 –1.00 –2.00 –3.00 2.00 .00 –2.00 –4.00 Difference inRVstrainmeasures Differenceof themeanRVFW strain Table 2 – Baseline characteristics of the patients treated with anthracyclines and trastuzumab - Association with cardiotoxicity. Variable Cardiotoxicity P Yes No n = 5 n = 44 Age (years) * ll 56.4 ± 9.50 48.9 ± 12.30 0.60 Weight (kg) * ll 65.8 ± 10.80 67.9 ± 12.90 0.78 Height (m) * ll 1.58 ± 0.07 1.57 ± 0.08 0.80 BSA (m 2 ) * ll 1.63 ± 0.17  1.66 ± 1.17 0.80 BMI (kg/m 2 ) †§ 27.3 (22.9-29.2) 26 (23.7-30.4) 0.94 SAH ‡ 2 (40%) 14 (31.8%) 0.53 White ethnicity ‡ 4 (80%) 27 (61.4%) 0.39 Mixed ethnicity ‡ 1 (20%) 17 (38.6%) Type II DM ‡ 1 (20%) 1 (2.3%) 0.20 ASA ‡ 1 (20%) 1 (2.3%) 0.20 Diuretic ‡ 2 (40%) 12 (27.3%) 0.45 Statin ‡ 0 3 (6.8%) 0. 72 SBP (mm Hg) ‡ ll 128 ± 23.9 124.8 ± 16.9 0.30 DBP (mm Hg) ‡ ll 72 ± 13.0 75 ± 12.0 0.88 HR (bpm) ‡ ll 78.4 ± 8.3 77.1 ± 10.4 0.78 Invasive ductal carcinoma ‡ 3 (60%) 31 (71%) Lobular carcinoma ‡ 2 (40%) 5 (11.4%) 0.17 Other types ‡ 0 8 (18.2%) FEC protocol ‡ 4 (80%) 27 (61.4%) 0.64 AC protocol ‡ 1 (20%) 17 (38.6%) Radiotherapy ‡ 4 (80%) 22 (50%) 0.35 Total Trastuzumab Dose (mg/m 2 ) * ll 4257 ± 1899 6692 ± 2352 0.24 Total Anthracycline Dose (Equivalent dose mg/m 2 ) † ll 480 (402-720) 600 (525-795) 0.17 * Mean (standard deviation); † Median (25 th - 75 th Percentile); ‡ N (%); BSA: Body Surface Area; BMI: Body Mass Index; SAH - Systemic Arterial Hypertension; DM: Diabetes Mellitus; ASA: Acetylsalicylic Acid; SBP: Systolic Blood Pressure; DBP: Diastolic Blood Pressure; HR: Heart Rate; FEC: 5-Fluorouracil + Epirubicin + Cyclophosphamide; AC: Doxorubicin + Cyclophosphamide. Categorical variables compared by use of chi-square test ‡ , p value ≤ 0.05. Continuous variables compared by use of Mann Whitney U test § or Student t test ll , p value ≤ 0.05. 144