ABC | Volume 110, Nº2, February 2018

Image Cardiac Lymphoma: A Rare Cause of Acute Heart Failure with Restrictive Physiology Fernando Garagoli, Ezequiel Guzzetti, Ezequiel Lillo, Luciano Lucas, César Belziti Hospital Italiano de Buenos Aires, Buenos Aires – Argentina Mailing Address: Fernando Garagoli • Peron 4190, C1183AEG, Ciudad Autónoma de Buenos Aires, Buenos Aires - Argentina E-mail: fernando.garagoli@hospitalitaliano.org.ar Manuscript received March 13, 2017, revised manuscript April 12, 2017, accepted April 12, 2017 Keywords Cardiovascular Diseases; Lymphoma; Heart Failure / physiopathology; Magnetic Resonance Imaging. DOI: 10.5935/abc.20180015 A 74-year-old woman with a history of membranous glomerulonephritis and a recent diagnosis of mediastinal adenopathy was admitted to the emergency department with acute heart failure. She complained of progressive dyspnea and weakness in the last week. Physical examination revealed hypotension, tachypnea, jugular vein distention, and desaturation. The most relevant laboratory findings were: anemia, lymphocytopenia, lactic acidosis, and increased lactate dehydrogenase. An electrocardiogram showed rapid atrial fibrillation and low-voltage QRS complexes. An echocardiogram revealed severe pericardial effusion and diffuse heterogeneous thickening of the ventricular and atrial walls. The patient requiredmechanical ventilation and inotropic support. Therapeutic pericardiocentesis was performed without clinical improvement. Cardiovascular magnetic resonance imaging (CMR) showed septal bounce (compatible with restrictive physiology) and a heterogeneous isointense mass surrounding the ventricular and atrial walls with late gadolinium enhancement of themyocardium and hypoenhancement of the tumor (Figure 1), compatible with primary cardiac lymphoma. A diagnosis of large B-cell lymphoma was confirmed by flow cytometry of the pericardial fluid. The patient died before starting chemotherapic treatment. Secondary involvement of the myocardium in patients with systemic lymphoma is relatively frequent (around 30% in disseminated non-Hodgkin lymphoma) whereas primary cardiac lymphoma is rare (1-2%). We present a case of acute heart failure with restrictive physiology secondary to cardiac lymphoma. In our experience, CMR was key to the final diagnosis. Author contributions Conception and design of the research: Garagoli F, Guzzetti E, Lillo E, Lucas L, Belziti C; Acquisition of data: Garagoli F, Guzzetti E, Lillo E; Analysis and interpretation of the data: Garagoli F, Guzzetti E, Lucas L; Statistical analysis: Garagoli F, Guzzetti E, Belziti C; Critical revision of the manuscript for intellectual content: Lucas L, Belziti C. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding There were no external funding sources for this study. Study Association This study is not associatedwith any thesis or dissertationwork. 203