ABC | Volume 110, Nº1, January 2018 Sociedade Brasileira de Cardiologia • ISSN-0066-782X • Volume 110, Nº 1, January 2018 Editorial New Editor-in-Chief, New Challenges Short Editorial Cardiovascular Risk Stratification: From Phenotype to Genotype? Cardioprotective Effects of Melatonin in Reperfusion Injury Original Articles Oral Anticoagulation in Atrial Fibrillation: Development and Evaluation of a Mobile Health Application to Support Shared Decision-Making Association of Multiple Genetic Variants with the Extension and Severity of Coronary Artery Disease Prognostic Accuracy of the GRACE Score in Octogenarians and Nonagenarians with Acute Coronary Syndromes Prevalence of Dyslipidemias in Three Regions in Venezuela: The VEMSOLS Study Results Leisure-Time Physical Activity, but not Commuting Physical Activity, is Associated with Cardiovascular Risk among ELSA‑Brasil Participants Melatonin-Induced Protective Effects on Cardiomyocytes Against Reperfusion Injury Partly Through Modulation of IP3R and SERCA2a Via Activation of ERK1 Correlation of Electrocardiographic Changes with Cardiac Magnetic Resonance Findings in Patients with Hypertrophic Cardiomyopathy Development and Psychometric Validation of HIPER-Q to Assess Knowledge of Hypertensive Patients in Cardiac Rehabilitation Sensitive Troponin I Assay in Patients with Chest Pain – Association with Significant Coronary Lesions with or Without Renal Failure Cardiac and Musculoskeletal Responses to the Effects of Passive and Active Tilt Test in Healthy Subjects Review Article Genetic Syndromes Associated with Congenital Cardiac Defects and Ophthalmologic Changes – Systematization for Diagnosis in the Clinical Practice Viewpoint Cognitive Deficit in Heart Failure and the Benefits of Aerobic Physical Activity Clinicoradiological Session Case 1/2018 – Preponderant Left Ventricular Restrictive Syndrome in a 28-Year-Old Woman Case Report Pregnancy in Woman with Kawasaki Disease and Multiple Coronary Artery Aneurysms Image Cor Triatriatum Sinistrum Letter to the Editor Cardiac Cachexia – A Window to the Wasting Disorders Figure 3 – Melatonin protects F-actin organization in H9C2 cells against H/R via ERK1 in vitro. Representative confocal microscopy images show H9C2 cells stained with FITC-phalloidin. The results showed that simulated H/R induced more diffuse and irregular actin disposition compared with control group. Melatonin preserved more regular and well-defined actin organization and PD98059 (ERK1 inhibitor) reduced the protection of melatonin. bar = 20μm. (Control: control group; H/R:H/R group; H/R+mel: H/R+ melatonin group; H/R+mel+PD: H/R+ melatonin+PD98059 group). Page 48 Control H/R H/R+Mel H/R+Mel+PD